Thomas Bjorn R, Tan Xiang L, Javadzadeh Shagayegh, Robinson Elizabeth J, McDonald Bryan S, Krupiczojc Malvina A, Rahman Syedia R, Rahman Samiha, Ahmed Rehana A, Begum Rubina, Khanam Habiba, Kelsell David P, Grigg Jonathan, Knell Robert J, O'Toole Edel A
Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Department of Dermatology, The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.
JID Innov. 2021 Oct 9;2(1):100062. doi: 10.1016/j.xjidi.2021.100062. eCollection 2022 Jan.
Atopic eczema is a common and complex disease. Missing genetic hereditability and increasing prevalence in industrializing nations point toward an environmental driver. We investigated the temporal association of weather and pollution parameters with eczema severity. This cross-sectional clinical study was performed between May 2018 and March 2020 and is part of the Tower Hamlets Eczema Assessment. All participants had a diagnosis of eczema, lived in East London, were of Bangladeshi ethnicity, and were aged <31 years. The primary outcome was the probability of having an Eczema Area and Severity Index score > 10 after previous ambient exposure to commonly studied meteorological variables and pollutants. There were 430 participants in the groups with Eczema Area and Severity Index ≤ 10 and 149 in those with Eczema Area and Severity Index > 10. Using logistic generalized additive models and a model selection process, we found that tropospheric ozone averaged over the preceding 270 days was strongly associated with eczema severity alongside the exposure to fine particles with diameters of 2.5 μm or less (fine particulate matter) averaged over the preceding 120 days. In our models and analyses, fine particulate matter appeared to largely act in a supporting role to ozone. We show that long-term exposure to ground-level ozone at high levels has the strongest association with eczema severity.
特应性皮炎是一种常见且复杂的疾病。遗传遗传性缺失以及工业化国家患病率的上升表明存在环境驱动因素。我们研究了天气和污染参数与湿疹严重程度的时间关联。这项横断面临床研究于2018年5月至2020年3月进行，是塔哈姆雷特湿疹评估的一部分。所有参与者均被诊断为湿疹，居住在东伦敦，为孟加拉族裔，年龄小于31岁。主要结局是在先前暴露于常见研究的气象变量和污染物后，湿疹面积及严重程度指数评分>10的概率。湿疹面积及严重程度指数≤10的组中有430名参与者，湿疹面积及严重程度指数>10的组中有149名参与者。使用逻辑广义相加模型和模型选择过程，我们发现，在前270天内平均的对流层臭氧与湿疹严重程度密切相关，同时在前120天内平均的直径为2.5μm或更小的细颗粒物（细颗粒物）暴露也与之密切相关。在我们的模型和分析中，细颗粒物似乎在很大程度上对臭氧起支持作用。我们表明，长期高水平暴露于地面臭氧与湿疹严重程度的关联最强。
