Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran.
Dig Dis Sci. 2022 Aug;67(8):3632-3638. doi: 10.1007/s10620-021-07368-6. Epub 2022 Jan 6.
Zinc is known to have a critical role in the maintenance of intestinal homeostasis, immune cells, and anti-diarrheal and anti-inflammatory actions.
The aim of this study was to evaluate the correlation between zinc status with serum zonulin and gastrointestinal symptoms in diarrhea-predominant patients with irritable bowel syndrome (IBS-D).
This case-control study included 61 newly diagnosed IBS-D patients and 61 healthy matched controls. Dietary zinc intake, serum zinc, and zonulin levels were measured. IBS severity was evaluated using the IBS severity score system (IBS-SSS) questionnaire.
Serum zinc levels were lower in the IBS-D group compared with the controls (p = 0.001). Serum zinc was negatively correlated with serum zonulin in IBS-D patients (r = - 0.271; p = 0.035). Also, a reverse association between the serum zinc and odds of IBS-D was found [OR = 0.979; 95% CI (0.966-0.992)].
Our results suggest that zinc may have a role in the pathogenesis of IBS. However, clinical trial studies are warranted to evaluate this finding.
锌在维持肠道内环境稳定、免疫细胞功能以及抗腹泻和抗炎方面具有重要作用。
本研究旨在评估锌状态与腹泻型肠易激综合征（IBS-D）患者血清肠通透素和胃肠道症状之间的相关性。
本病例对照研究纳入了 61 例新诊断的 IBS-D 患者和 61 例健康匹配对照。测量了膳食锌摄入量、血清锌和肠通透素水平。使用 IBS 严重程度评分系统（IBS-SSS）问卷评估 IBS 严重程度。
与对照组相比，IBS-D 组的血清锌水平较低（p=0.001）。IBS-D 患者的血清锌与血清肠通透素呈负相关（r=-0.271；p=0.035）。此外，还发现血清锌与 IBS-D 发生的比值比之间存在反向关联[OR=0.979；95%CI（0.966-0.992）]。
我们的研究结果表明，锌可能在 IBS 的发病机制中发挥作用。然而，需要进行临床试验研究来评估这一发现。
