Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran.
Sci Rep. 2022 Jun 29;12(1):11002. doi: 10.1038/s41598-022-15080-2.
Zinc is an important trace element for structure, and regulation in the central nervous system, as well as the gut homeostasis. There are several mental disorders associated with zinc deficiency. The relationship between zinc nutritional status with mood states and quality of life (QoL) in diarrhea-predominant irritable bowel syndrome (IBS-D) has not been studied yet. This case-control study aimed to investigate the association between zinc nutritional status with mood states and QoL in IBS-D patients. Sixty-one newly diagnosed patients with IBS-D and 61 matched healthy controls were enrolled. Dietary zinc intakes and serum zinc levels were measured. Mood states and QoL were evaluated by validated questionnaires. Logistic regression was used to estimate the odds of IBS-D in relation to zinc deficiency. Decreased serum zinc levels were observed in the IBS-D group than in the controls (p = 0.001). There were higher scores of depression (p = 0.014), anxiety (p = 0.005), and stress (p = 0.001) among IBS-D patients. Moreover, overall QoL, physical and psychological health were lower in IBS-D patients compared to the controls (p < 0.001). "Food avoidance" had the lowest, while the "relationship" had the highest score among the patients (51.09 ± 26.80 and 78.14 ± 23.30, respectively). Dietary zinc intake was positively correlated with psychological health in the controls (r = 0.295, p = 0.022) and with body image in the patients (r = 0.266, p = 0.044). According to the logistic regression, zinc deficiency was not significantly associated with odds of IBS-D. Findings show that zinc deficiency may be associated with some parameters of IBS-D. Further clinical studies are needed to explore the causal relationship between zinc status and IBS pathogenesis.
锌是中枢神经系统结构和调节以及肠道内稳态的重要微量元素。有几种精神疾病与缺锌有关。锌营养状况与腹泻为主的肠易激综合征（IBS-D）患者的情绪状态和生活质量（QoL）之间的关系尚未研究。本病例对照研究旨在探讨 IBS-D 患者锌营养状况与情绪状态和 QoL 的关系。纳入 61 例新诊断的 IBS-D 患者和 61 例匹配的健康对照者。测量膳食锌摄入量和血清锌水平。使用经过验证的问卷评估情绪状态和 QoL。使用逻辑回归估计与锌缺乏相关的 IBS-D 发生的几率。与对照组相比，IBS-D 组的血清锌水平降低（p=0.001）。IBS-D 患者的抑郁（p=0.014）、焦虑（p=0.005）和压力评分较高（p=0.001）。此外，与对照组相比，IBS-D 患者的总体 QoL、身体和心理健康状况较低（p<0.001）。在患者中，“食物回避”的评分最低，而“关系”的评分最高（分别为 51.09±26.80 和 78.14±23.30）。在对照组中，膳食锌摄入量与心理健康呈正相关（r=0.295，p=0.022），在患者中与身体形象呈正相关（r=0.266，p=0.044）。根据逻辑回归，锌缺乏与 IBS-D 的几率无显著相关性。研究结果表明，锌缺乏可能与 IBS-D 的某些参数有关。需要进一步的临床研究来探讨锌状态与 IBS 发病机制之间的因果关系。
