Faculty of Medicine, Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Clin Exp Hypertens. 2022 Apr 3;44(3):223-227. doi: 10.1080/10641963.2021.2018601. Epub 2022 Jan 7.
There is strong evidence that oxidative stress and inflammation may contribute to the coronary artery ectasia (CAE) pathophysiology. Recent studies have shown that serum irisin and adropin levels are associated with oxidative stress and inflammation. In the light of this information, we aimed to investigate the possible relationship between serum irisin, adropin levels and CAE.
PATIENTS & METHODS: A total of 50 consecutive patients with CAE and 50 consecutive patients with normal coronary anatomy (NCA) were enrolled into the study. Serum irisin, adropin and other clinical parameters were compared between groups.
Adropin ( < .001) and irisin ( < .001) levels were lower in the CAE group. Low adropin ( = .014) and irisin ( < .001) levels were detected as an independent risk factor for CAE in multiple regression analysis. Receiver operating characteristic curve analysis showed that serum adropin ( < .001) and irisin ( < .001) leves was significant predictor of CAE.
The results of this study showed that serum irisin and adropin level was lower in the CAE group than in the NCA group. Irisin and adropin could play a role in the pathogenesis of CAE.
有强有力的证据表明氧化应激和炎症可能导致冠状动脉扩张（CAE）的病理生理学。最近的研究表明，血清鸢尾素和阿屈波汀水平与氧化应激和炎症有关。鉴于此信息，我们旨在研究血清鸢尾素、阿屈波汀水平与 CAE 之间的可能关系。
共纳入 50 例连续的 CAE 患者和 50 例连续的正常冠状动脉解剖（NCA）患者。比较两组患者的血清鸢尾素、阿屈波汀和其他临床参数。
CAE 组的阿屈波汀（<0.001）和鸢尾素（<0.001）水平较低。多变量回归分析显示，低阿屈波汀（=0.014）和鸢尾素（<0.001）水平是 CAE 的独立危险因素。受试者工作特征曲线分析表明，血清阿屈波汀（<0.001）和鸢尾素（<0.001）水平是 CAE 的显著预测因子。
本研究结果表明，CAE 组血清鸢尾素和阿屈波汀水平低于 NCA 组。鸢尾素和阿屈波汀可能在 CAE 的发病机制中发挥作用。
