Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt Institute for Infection, Immunology and Inflammation, Department of Molecular Physiology and Biophysics and Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN.
Circ Res. 2022 Jan 7;130(1):130-148. doi: 10.1161/CIRCRESAHA.121.319822.
Resolution is an active and highly coordinated process that occurs in response to inflammation to limit tissue damage and promote repair. When the resolution program fails, inflammation persists. It is now understood that failed resolution is a major underlying cause of many chronic inflammatory diseases. Here, we will review the major failures of resolution in atherosclerosis, including the imbalance of proinflammatory to pro-resolving mediator production, impaired clearance of dead cells, and functional changes in immune cells that favor ongoing inflammation. In addition, we will briefly discuss new concepts that are emerging as possible regulators of resolution and highlight the translational significance for the field.
分辨率是一个主动和高度协调的过程，发生在响应炎症，以限制组织损伤和促进修复。当分辨率程序失败时，炎症持续存在。现在人们已经了解到，分辨率的失败是许多慢性炎症性疾病的主要潜在原因。在这里，我们将回顾动脉粥样硬化中分辨率的主要失败，包括促炎介质到促分辨率介质产生的失衡，死亡细胞清除受损，以及有利于持续炎症的免疫细胞的功能变化。此外，我们还将简要讨论作为分辨率可能调节剂的新概念，并强调该领域的转化意义。
