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动脉粥样硬化中巨噬细胞相关免疫调节的文献计量分析：发病机制研究进展

A bibliometric analysis of macrophage-associated immune regulation in atherosclerosis: advances in the mechanisms of pathogenesis.

作者信息

Jiang Meiling, Han Tianci, Li Xianhui, Zhu Guofu

机构信息

Cardiology Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

出版信息

Front Immunol. 2025 Jun 12;16:1559360. doi: 10.3389/fimmu.2025.1559360. eCollection 2025.

DOI:10.3389/fimmu.2025.1559360
PMID:40574833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12197927/
Abstract

BACKGROUND: The occurrence and development of atherosclerosis (AS) is closely related to immune regulation. Macrophages serve as the primary immune cells involved in AS. However, the mechanisms underlying macrophage-mediated immune regulation in AS remain inadequately understood, necessitating the development of novel immunotherapeutic strategies. This article aims to review the current status and emerging trends in macrophage immune regulation related to AS on a global scale. METHODS: We utilized the Web of Science Core Collection database to identify articles pertaining to macrophage immune regulation in AS published between 2000 and 2024. Bibliometric methods were used to analyze authors, institutions, countries, journals and references through CiteSpace and VOSviewer. A total of 1469 articles were included in this study. RESULTS: The United States has published the highest number of articles in this field, followed closely by China. Maastricht University stands out as a leading institution specializing in macrophage immune regulation related to AS. Esther Lutgens from Germany has made significant contributions to this area of research. The authors identified "Arteriosclerosis, Thrombosis, and Vascular Biology" as the most influential journal within this domain. Through cluster analysis, the keywords were categorized into four primary groups: (1) autoantibodies, (2) activation, (3) immune activation, and (4) nuclear receptors. CONCLUSION: This study systematically summarizes the findings of macrophage immune regulation research in AS from 2000 to 2024, while also describing and predicting global research hotspots and trends. The investigation into the molecular mechanisms underlying macrophage immune regulation in AS is poised to become a prominent topic in future studies.

摘要

背景：动脉粥样硬化（AS）的发生发展与免疫调节密切相关。巨噬细胞是参与AS的主要免疫细胞。然而，巨噬细胞介导的AS免疫调节机制仍未得到充分理解，因此需要开发新的免疫治疗策略。本文旨在综述全球范围内与AS相关的巨噬细胞免疫调节的现状和新趋势。 方法：我们利用Web of Science核心合集数据库识别2000年至2024年间发表的与AS中巨噬细胞免疫调节相关的文章。通过CiteSpace和VOSviewer使用文献计量学方法分析作者、机构、国家、期刊和参考文献。本研究共纳入1469篇文章。 结果：美国在该领域发表的文章数量最多，中国紧随其后。马斯特里赫特大学是专注于与AS相关的巨噬细胞免疫调节的领先机构。来自德国的埃丝特·卢特根斯在这一研究领域做出了重大贡献。作者们确定《动脉硬化、血栓形成和血管生物学》是该领域最具影响力的期刊。通过聚类分析，关键词被分为四个主要组：（1）自身抗体，（2）激活，（3）免疫激活，（4）核受体。 结论：本研究系统总结了2000年至2024年AS中巨噬细胞免疫调节研究的结果，同时也描述和预测了全球研究热点和趋势。对AS中巨噬细胞免疫调节分子机制的研究有望成为未来研究的一个突出主题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/8d35ce67cc4b/fimmu-16-1559360-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/28822556c4b7/fimmu-16-1559360-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/efaf9e290584/fimmu-16-1559360-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/7e7c6150b3dd/fimmu-16-1559360-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/2aa64bce7a2c/fimmu-16-1559360-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/8d35ce67cc4b/fimmu-16-1559360-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/c58ea8e0ca9f/fimmu-16-1559360-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/e8f524bd5cb5/fimmu-16-1559360-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/771c7f6445b6/fimmu-16-1559360-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/ad4cd43396bb/fimmu-16-1559360-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/2961b8cb84f5/fimmu-16-1559360-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/28822556c4b7/fimmu-16-1559360-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/efaf9e290584/fimmu-16-1559360-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/7e7c6150b3dd/fimmu-16-1559360-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/88ae8206721e/fimmu-16-1559360-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/2aa64bce7a2c/fimmu-16-1559360-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f9/12197927/8d35ce67cc4b/fimmu-16-1559360-g011.jpg

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本文引用的文献

[1]
Role of STING Deficiency in Amelioration of Mouse Models of Lupus and Atherosclerosis.

Arthritis Rheumatol. 2025-5

[2]
Artificial intelligence alphafold model for molecular biology and drug discovery: a machine-learning-driven informatics investigation.

Mol Cancer. 2024-10-5

[3]
Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases.

Curr Atheroscler Rep. 2024-10

[4]
Adiponectin and Adiponectin Receptors in Atherosclerosis.

Endocr Rev. 2025-1-10

[5]
Crosstalk between Inflammation and Atherosclerosis in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Is There a Common Basis?

Life (Basel). 2024-5-31

[6]
Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function.

J Biol Chem. 2024-6

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Immun Ageing. 2024-5-2

[8]
Itaconate as a key player in cardiovascular immunometabolism.

Free Radic Biol Med. 2024-7

[9]
Breaking tolerance: the autoimmune aspect of atherosclerosis.

Nat Rev Immunol. 2024-9

[10]
Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice.

J Clin Invest. 2023-12-12

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