Department of Cardiovascular Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Department of Cardiovascular Surgery, China-Japan Friendship Hospital, Beijing, China.
J Cell Physiol. 2021 Oct;236(10):7159-7175. doi: 10.1002/jcp.30366. Epub 2021 Mar 23.
Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflammatory cytokines (such as interleukin IL-1β and IL-18). Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.
动脉粥样硬化是一种严重的心血管疾病负担，也是全球范围内的主要死亡原因，被认为是一种慢性非感染性炎症性疾病。细胞焦亡是一种新型的促炎调控性细胞死亡，其特征为细胞肿胀、细胞膜起泡和促炎细胞因子（如白细胞介素-1β和白细胞介素-18）的强烈释放。越来越多的研究表明细胞焦亡对动脉粥样硬化有重要贡献，并阐明了针对动脉粥样硬化的细胞焦亡治疗靶点候选药物。本文综述了细胞焦亡的初步特征、细胞焦亡的详细机制、细胞焦亡与动脉粥样硬化的现有证据，以及针对动脉粥样硬化发生过程中细胞焦亡的潜在治疗策略。
