Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Cancer Epidemiol. 2022 Feb;76:102092. doi: 10.1016/j.canep.2021.102092. Epub 2022 Jan 5.
Soluble tumor necrosis factor receptor-II (sTNF-R2), a pro-inflammatory biomarker, is associated with obesity and breast cancer (BC). The association between sTNF-R2 and risk of mortality after BC has not been studied, specifically among Hispanic women, an at-risk population due to their high prevalence of obesity and poor prognosis. We examined the association between sTNF-R2 and mortality among Hispanic and non-Hispanic white (NHW) BC survivors.
A total of 397 invasive BC survivors (96 Hispanic, 301 NHW) contributed baseline interview data and blood samples. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression models adjusting for clinical factors including body mass index.
After a median follow-up time of 13 years, 133 deaths occurred. The association between high vs low levels of plasma sTNF-R2 and mortality was not statistically significant overall (HR, 1.32; 95% CI 0.89-1.98). However, when stratified the mortality risk among Hispanic women was nearly 3-fold (HR, 2.83; 95% CI 1.21-6.63), while risk among NHW women was attenuated (HR, 0.99; 95% CI 0.61-1.61) (p-interaction=0.10).
Our results suggest Hispanic BC survivors with high sTNF-R2 levels may have increased risk of mortality and could inform targeted interventions to reduce inflammation and improve outcomes.
可溶性肿瘤坏死因子受体-II（sTNF-R2）是一种促炎生物标志物，与肥胖和乳腺癌（BC）有关。sTNF-R2 与 BC 后死亡率之间的关系尚未得到研究，特别是在 Hispanic 女性中，由于肥胖和预后不良的高发率，她们是高危人群。我们研究了 sTNF-R2 与 Hispanic 和非 Hispanic 白种人（NHW）BC 幸存者死亡率之间的关系。
共有 397 名浸润性 BC 幸存者（96 名 Hispanic，301 名 NHW）提供了基线访谈数据和血液样本。使用 Cox 比例风险回归模型计算风险比（HR）和 95%置信区间（CI），调整了包括体重指数在内的临床因素。
在中位随访时间为 13 年期间，有 133 例死亡。血浆 sTNF-R2 高水平与低水平与死亡率之间的关联在总体上无统计学意义（HR，1.32；95%CI，0.89-1.98）。然而，当按 Hispanic 女性分层时，死亡率风险几乎增加了 3 倍（HR，2.83；95%CI，1.21-6.63），而 NHW 女性的风险则减弱（HR，0.99；95%CI，0.61-1.61）（p 交互作用=0.10）。
我们的结果表明，sTNF-R2 水平高的 Hispanic BC 幸存者可能有更高的死亡风险，这可能为靶向干预提供信息，以减少炎症并改善预后。
