n-3 多不饱和脂肪酸在肥胖症棕色脂肪组织和产热调节中的作用：与肠道微生物群的潜在关系。
n-3 polyunsaturated fatty acids in the regulation of adipose tissue browning and thermogenesis in obesity: Potential relationship with gut microbiota.
机构信息
Escuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Departamento de Nutricion, Facultad de Medicina, Universidad de Chile, Santiago, Chile; Nutritional Sciences Department, Faculty of Medicine, University of Toronto, Toronto ON, Canada.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2022 Feb;177:102388. doi: 10.1016/j.plefa.2021.102388. Epub 2021 Dec 29.
BACKGROUND
Obesity is a worldwide public health problem characterized by fat tissue accumulation, favouring adipose tissue and metabolic alterations. Increasing energy expenditure (EE) through brown adipose tissue activation and white adipose tissue (WAT) browning has gained relevance as a therapeutic approach. Different bioactive compounds, such as n-3 polyunsaturated fatty acids (PUFA), have been shown to induce those thermogenic effects. This process is regulated by the gut microbiota as well. Nevertheless, obesity is characterized by gut microbiota dysbiosis, which can be restored by weight loss and n-3 PUFA intake, among other factors. Knowledge gap: However, the role of the gut microbiota on the n-3 PUFA effect in inducing thermogenesis in obesity has not been fully elucidated.
OBJECTIVE
This review aims to elucidate the potential implications of this interrelation on WAT browning adiposw sittue (BAT), BAT activity, and EE regulation in obesity models.
背景
肥胖是一种全球性的公共健康问题，其特征是脂肪组织积累，有利于脂肪组织和代谢改变。通过棕色脂肪组织激活和白色脂肪组织（WAT）褐变来增加能量消耗（EE）已成为一种治疗方法。不同的生物活性化合物，如 n-3 多不饱和脂肪酸（PUFA），已被证明具有诱导这些产热作用。这一过程也受到肠道微生物群的调节。然而，肥胖的特征是肠道微生物群失调，这可以通过减肥和 n-3 PUFA 的摄入等因素来恢复。知识空白：然而，肠道微生物群在 n-3 PUFA 诱导肥胖中产热作用中的作用尚未完全阐明。
目的
本综述旨在阐明这种相互关系对肥胖模型中 WAT 褐变、BAT 活性和 EE 调节的潜在影响。
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