Khafaji Mona, Bavi Omid, Zamani Masoud
Institute for Nanoscience and Nanotechnology, Sharif University of Technology, 14588-89694 Tehran, Iran.
Department of Mechanical and Aerospace Engineering, Shiraz University of Technology, 71557-13876 Shiraz, Iran.
Biophys Rev. 2022 Jan 29;14(1):317-326. doi: 10.1007/s12551-021-00926-2. eCollection 2022 Feb.
The early diagnosis together with an efficient therapy of cancer is essential to treat cancer patients and to enhance their quality of life. The use of nanostructures, as a newer technology, has demonstrated proven benefits as efficient cancer theranostic agents in numerous recent studies. Having a tunable surface plasmon resonance, gold nanostructures have been the subject of many recent studies as excellent imaging and photothermal therapy agents. However, the potential cytotoxicity and weak stability of gold nanostructures necessitate further modifications using biocompatible materials for biological applications. Based on the composition of the final structure, these gold-based hybrid nanostructures (GHNs) could be divided into five major groups; each of which has specific pros and cons. Understanding the strengths and weaknesses of each group helps scientists to optimize GHN designs with multiple functions by synergizing the benefits of different groups. This review aims to summarize the advancements in GHN design and provide a perspective view of future requirements for successful GHN-based targeted combinational cancer theranostic platforms.
癌症的早期诊断与有效治疗对于治疗癌症患者和提高其生活质量至关重要。作为一种较新的技术，纳米结构的应用在众多近期研究中已被证明作为高效的癌症诊疗剂具有显著益处。由于具有可调谐的表面等离子体共振，金纳米结构作为出色的成像和光热治疗剂成为了许多近期研究的主题。然而，金纳米结构潜在的细胞毒性和较弱的稳定性使得在生物应用中需要使用生物相容性材料进行进一步修饰。基于最终结构的组成，这些金基混合纳米结构（GHNs）可分为五大类；每一类都有其特定的优缺点。了解每一类的优缺点有助于科学家通过整合不同类别的优势来优化具有多种功能的GHN设计。本综述旨在总结GHN设计方面的进展，并对基于GHN的成功靶向联合癌症诊疗平台的未来要求提供前瞻性观点。
