Riken Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Ex Bhabha Atomic Research Center, Foundation for Education and Research, Mumbai, Maharashtra, India.
Nutr Cancer. 2023;75(2):430-449. doi: 10.1080/01635581.2022.2135744. Epub 2022 Oct 20.
Flavonoids are polyphenolic phytochemicals, which occur naturally in plants and possess both anti-oxidant and pro-oxidant properties. Flavonoids are gaining increasing popularity in the pharmaceutical industry as healthy and cost-effective compounds. Flavonoids show beneficial pharmacological activities in the treatment and prevention of various types of diseases. They are natural and less toxic agents for cancer chemotherapy and radiotherapy via regulation of multiple cell signaling pathways and pro-oxidant effects. In this review, we have summarized the mechanisms of action of selected flavonoids, and their pharmacological implications and potential therapeutic applications in cancer therapy.
类黄酮是多酚类植物化学物质，天然存在于植物中，具有抗氧化和促氧化特性。类黄酮作为健康且具有成本效益的化合物，在制药行业越来越受欢迎。类黄酮在治疗和预防各种疾病方面表现出有益的药理活性。它们是癌症化疗和放疗的天然、低毒药物，通过调节多种细胞信号通路和促氧化作用。在这篇综述中，我们总结了选定类黄酮的作用机制及其在癌症治疗中的药理意义和潜在治疗应用。
