Dr Khandaker Abu Talha, Associate Professor of Neurosurgery, Sylhet Women's Medical College, Sylhet, Bangladesh; E-mail:
Mymensingh Med J. 2022 Jan;31(1):216-222.
Zinc is one of the important trace elements of blood. It helps in maturation of immune system in our body. In the past studies originate the relationship between viral disease and serum zinc deficiency. This was a multicenter case-control study to measure the serum zinc level of COVID-19 patients with different respiratory supports and to evaluate the Odds Ratio (OR) and Relative risk (RR) of zinc deficiency for oxygen requirement for COVID-19 patients. Study places were COVID-19 unit of three tertiary hospitals of Sylhet, a Northern district of Bangladesh. There were 30 controls and 90 cases in this study. The mean zinc level of cases (53-38mcg/dl) was significantly (p=0.000072) lower than the level of controls (73-23mcg/dl). The mean zinc level of the COVID-19 patients required oxygen (49-33mcg/dl) was significantly (p=0.0054) lower than the patients were not treated by oxygen therapy (64-51mcg/dl). The RR of getting affected by COVID-19 was 1-91 for the low zinc level people. Among the COVID-19 affected participants the lower zinc level people had a RR of 1-93 to receive oxygen supplementation. Lower zinc level people are more likely to be affected by COVID-19 in comparison to the normal zinc level people. Among the COVID-19 patients the lower zinc level people had nearly double (RR 1-93) risk of becoming hypoxic and eventually prone for oxygen support.
锌是血液中的重要微量元素之一。它有助于人体免疫系统的成熟。过去的研究表明病毒疾病与血清锌缺乏之间存在关系。这是一项多中心病例对照研究，旨在测量不同呼吸支持的 COVID-19 患者的血清锌水平，并评估 COVID-19 患者对氧气需求的锌缺乏症的优势比（OR）和相对风险（RR）。研究地点是孟加拉国北部锡尔赫特的三家三级医院的 COVID-19 病房。本研究中有 30 名对照和 90 例病例。病例组的平均锌水平（53-38mcg/dl）明显（p=0.000072）低于对照组（73-23mcg/dl）。需要氧气治疗的 COVID-19 患者（49-33mcg/dl）的平均锌水平明显（p=0.0054）低于未接受氧疗的患者（64-51mcg/dl）。锌水平低的人患 COVID-19 的 RR 为 1-91。在受 COVID-19 影响的参与者中，锌水平较低的人接受氧补充的 RR 为 1-93。与正常锌水平的人相比，锌水平较低的人更容易受到 COVID-19 的影响。在 COVID-19 患者中，锌水平较低的人患低氧血症的风险几乎增加了一倍（RR 1-93），最终容易接受氧气支持。
