单核细胞在与自然麻疹病毒感染相关的免疫抑制中作用的体外研究。

In vitro studies of the role of monocytes in the immunosuppression associated with natural measles virus infections.

作者信息

Griffin D E, Johnson R T, Tamashiro V G, Moench T R, Jauregui E, Lindo de Soriano I, Vaisberg A

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

出版信息

Clin Immunol Immunopathol. 1987 Dec;45(3):375-83. doi: 10.1016/0090-1229(87)90090-0.

DOI:10.1016/0090-1229(87)90090-0

PMID:3500003

Abstract

Measles is associated with suppression of mitogen-induced proliferative responses. The role of monocytes in depressed responses to phytohemagglutinin during measles was assessed. Depleting peripheral blood mononuclear cells of adherent cells decreased, increased, and did not change proliferative responses in essentially equal numbers of individuals. Inhibition of prostaglandin synthesis by indomethacin significantly increased proliferation (P = 0.009) but often not to normal values. Addition of supplemental interleukin 1 had little effect. Addition of supplemental natural interleukin 2 significantly increased proliferation (P = 0.002) even in patients with very low responses. These data suggest that monocyte function is abnormal in some individuals with measles, that the abnormality is variable, and that lymphocyte response to monocyte signals is probably suboptimal as well.

摘要

麻疹与丝裂原诱导的增殖反应受抑制有关。评估了单核细胞在麻疹期间对植物血凝素反应降低中的作用。去除外周血单个核细胞中的贴壁细胞，在数量基本相同的个体中，增殖反应分别出现降低、增加和无变化的情况。吲哚美辛抑制前列腺素合成可显著增加增殖（P = 0.009），但通常达不到正常水平。添加补充性白细胞介素1作用不大。添加补充性天然白细胞介素2即使在反应非常低的患者中也能显著增加增殖（P = 0.002）。这些数据表明，在一些麻疹患者中单核细胞功能异常，这种异常是可变的，并且淋巴细胞对单核细胞信号的反应可能也未达到最佳状态。