School of Medical Sciences & Technology, Indian Institute of Technology Kharagpur, Kharagpur, 721302, West Bengal, India.
Nanomedicine (Lond). 2022 Jan;17(2):107-132. doi: 10.2217/nnm-2021-0348. Epub 2022 Jan 10.
Rapid vascular growth, infiltrative cells and high tumor heterogenicity are some glioblastoma multiforme (GBM) characteristics, making it the most lethal form of brain cancer. Low efficacy of the conventional treatment modalities leads to rampant disease progression and a median survival of 15 months. Magnetic nanoparticles (MNPs), due to their unique physical features/inherent abilities, have emerged as a suitable theranostic platform for targeted GBM treatment. Thus, new strategies are being designed to enhance the efficiency of existing therapeutic techniques such as chemotherapy, radiotherapy, and so on, using MNPs. Herein, the limitations of the current therapeutic strategies, the role of MNPs in mitigating those inadequacies, recent advances in the MNP-based theranostics of GBM and possible future directions are discussed.
快速血管生长、浸润细胞和高肿瘤异质性是胶质母细胞瘤（GBM）的一些特征，使其成为最致命的脑癌形式。传统治疗方式的疗效低下导致疾病迅速进展，中位生存期为 15 个月。由于其独特的物理特性/固有能力，磁性纳米粒子（MNPs）已成为靶向 GBM 治疗的一种合适的治疗平台。因此，正在设计新的策略来提高现有治疗技术（如化疗、放疗等）的效率，使用 MNPs。本文讨论了当前治疗策略的局限性、MNPs 在减轻这些不足方面的作用、基于 MNP 的 GBM 治疗的最新进展以及可能的未来方向。
