Yao Hongqing, Zhou Jian-Ying
Department of Nursing Care, Shanghai Songjiang District Central Hospital, Shanghai, China.
Front Bioeng Biotechnol. 2023 Jul 19;11:1248283. doi: 10.3389/fbioe.2023.1248283. eCollection 2023.
The effective treatment of glioblastoma still remains a great challenge. We herein report the development of chlorin e6 (Ce6)-conjugated iron oxide (FeO-Ce6) nanoparticles for ablation of glioblastoma cells via combining photothermal therapy (PTT) with photodynamic therapy (PDT). Ce6 was conjugated to the synthesized FeO nanoparticles to form FeO-Ce6 nanoparticles displaying the optical property of Ce6. Under 808 nm laser irradiation, FeO-Ce6 nanoparticles generated heat and the temperature increase did not have obvious changes after five cycles of laser irradiation, suggesting their good photothermal effect and photothermal stability. In addition, 660 nm laser irradiation of FeO-Ce6 nanoparticles produced singlet oxygen (O) to mediate PDT. The FeO-Ce6 nanoparticles without laser irradiation showed a low cytotoxicity, but they would obviously kill C6 cancer cells after laser irradiation via the combinational effect of PTT and PDT. FeO-Ce6 nanoparticles thus could be used as a nanotherapeutic agent for combinational ablation of glioblastoma cells.
胶质母细胞瘤的有效治疗仍然是一项巨大挑战。我们在此报告了通过将光热疗法（PTT）与光动力疗法（PDT）相结合，开发用于消融胶质母细胞瘤细胞的二氢卟吩e6（Ce6）共轭氧化铁（FeO-Ce6）纳米颗粒。Ce6与合成的FeO纳米颗粒共轭，形成具有Ce6光学特性的FeO-Ce6纳米颗粒。在808nm激光照射下，FeO-Ce6纳米颗粒产生热量，并且在五个激光照射循环后温度升高没有明显变化，表明它们具有良好的光热效应和光热稳定性。此外，对FeO-Ce6纳米颗粒进行660nm激光照射会产生单线态氧（O）以介导PDT。未进行激光照射的FeO-Ce6纳米颗粒显示出低细胞毒性，但在激光照射后，它们会通过PTT和PDT的联合作用明显杀死C6癌细胞。因此，FeO-Ce6纳米颗粒可作为一种纳米治疗剂用于联合消融胶质母细胞瘤细胞。
