Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17121, Sweden.
School of Medicine, Yunnan University, Kunming 650091, Yunnan, China.
J Control Release. 2021 Jul 10;335:437-448. doi: 10.1016/j.jconrel.2021.05.042. Epub 2021 Jun 1.
Cancer is one of the leading causes of mortality worldwide. Nanoparticles have been broadly studied and emerged as a novel approach in diagnosis and treatment of tumors. Over the last decade, researches have significantly improved magnetic nanoparticle (MNP)'s theranostic potential as nanomedicine for cancer. Newer MNPs have various advantages such as wider operating temperatures, smaller sizes, lower toxicity, simpler preparations and lower production costs. With a series of unique and superior physical and chemical properties, MNPs have great potential in medical applications. In particular, using MNPs as probes for medical imaging and carriers for targeted drug delivery systems. While MNPs are expected to be the future of cancer diagnosis and precision drug delivery, more research is still required to minimize their toxicity and improve their efficacy. An ideal MNP for clinical applications should be precisely engineered to be stable to act as tracers or deliver drugs to the targeted sites, release drug components only at the targeted sites and have minimal health risks. Our review aims to consolidate the recent improvements in MNPs for clinical applications as well as discuss the future research prospects and potential of MNPs in cancer theranostics.
癌症是全球主要死亡原因之一。纳米颗粒已被广泛研究,并成为肿瘤诊断和治疗的新方法。在过去的十年中,研究人员极大地提高了磁性纳米颗粒(MNP)作为癌症纳米医学的治疗诊断潜力。新型 MNP 具有更宽的工作温度、更小的尺寸、更低的毒性、更简单的制备方法和更低的生产成本等各种优势。MNP 具有一系列独特而优越的物理和化学性质,在医学应用中有很大的潜力。特别是将 MNP 用作医学成像的探针和靶向药物传递系统的载体。虽然 MNP 有望成为癌症诊断和精准药物输送的未来,但仍需要更多的研究来最小化其毒性并提高其疗效。对于临床应用而言,理想的 MNP 应该经过精确设计,以稳定地充当示踪剂或向靶向部位输送药物,仅在靶向部位释放药物成分,并且对健康风险最小。我们的综述旨在整合 MNP 在临床应用方面的最新进展,并讨论其在癌症治疗诊断方面的未来研究前景和潜力。
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