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小鼠小肠上皮内淋巴细胞的功能特性。III. 上皮内淋巴细胞无法诱导全身性移植物抗宿主反应是由于其在体内无法迁移。

Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.

作者信息

Baca M E, Mowat A M, MacKenzie S, Parrott D M

机构信息

Department of Bacteriology and Immunology, Western Infirmary, Glasgow.

出版信息

Gut. 1987 Oct;28(10):1267-74. doi: 10.1136/gut.28.10.1267.

Abstract

In this study we have investigated whether addition of bone marrow accessory cells or concurrent administration of recombinant IL-2 would allow intraepithelial lymphocytes (IEL) to induce a systemic, lethal GvHR in irradiated hosts. In addition we have studied the ability of IEL to migrate into lymphoid tissues after intravenous injection and compared this with their locomotor capacity in vitro.

摘要

在本研究中,我们调查了添加骨髓辅助细胞或同时给予重组白细胞介素-2是否能使上皮内淋巴细胞(IEL)在受辐照宿主中诱导全身性致死性移植物抗宿主反应(GvHR)。此外,我们研究了IEL静脉注射后迁移至淋巴组织的能力,并将其与它们在体外的运动能力进行了比较。

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