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1
Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.小鼠小肠上皮内淋巴细胞的功能特性。III. 上皮内淋巴细胞无法诱导全身性移植物抗宿主反应是由于其在体内无法迁移。
Gut. 1987 Oct;28(10):1267-74. doi: 10.1136/gut.28.10.1267.
2
Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli.小鼠小肠上皮内淋巴细胞的功能特性。II. 上皮内淋巴细胞对促有丝分裂和同种异体刺激的体内和体外反应。
Immunology. 1986 Aug;58(4):627-34.
3
Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition.肠上皮细胞源性白细胞介素-7：全肠外营养小鼠模型中上皮内淋巴细胞改变的一种机制。
Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G84-91. doi: 10.1152/ajpgi.00192.2006.
4
Functional properties of lymphocytes isolated from murine small intestinal epithelium.从小鼠小肠上皮分离的淋巴细胞的功能特性。
Immunology. 1984 Jul;52(3):501-9.
5
Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine.上皮内淋巴细胞计数和隐窝增生可衡量小鼠小肠移植物抗宿主反应的黏膜成分。
Gastroenterology. 1982 Aug;83(2):417-23.
6
Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine.从小鼠小肠与大肠分离的上皮内淋巴细胞T细胞亚群的差异。
J Immunol. 1995 Jun 1;154(11):5611-9.
7
Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine.黏膜免疫系统的区域特化。大肠的上皮内淋巴细胞与小肠的上皮内淋巴细胞具有不同的表型和功能。
J Immunol. 1993 Aug 15;151(4):1765-76.
8
GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy.由主要组织相容性复合体（MHC）I类或II类基因座产物引发的移植物抗宿主反应（GVHR）：分析小鼠T淋巴细胞对MHC I类和II类基因座产物的反应与GVHR诱导的死亡率、骨髓发育不全和肠病的相关性。
J Immunol. 1985 Sep;135(3):1637-43.
9
Reconstitution of lymphoid tissues under the influence of a subclinical level of graft versus host reaction induced by bone marrow T cells or splenic T cell subsets.在骨髓T细胞或脾T细胞亚群诱导的亚临床水平移植物抗宿主反应影响下淋巴组织的重建。
Cell Immunol. 1993 Oct 1;151(1):118-32. doi: 10.1006/cimm.1993.1226.
10
Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal.小肠肠病：上皮内淋巴细胞和细胞因子（白细胞介素-12、干扰素-γ、肿瘤坏死因子）在诱导上皮细胞死亡和更新中的作用。
Eur J Immunol. 1998 Feb;28(2):730-44. doi: 10.1002/(SICI)1521-4141(199802)28:02<730::AID-IMMU730>3.0.CO;2-U.

引用本文的文献

1
Functional properties of intra-epithelial lymphocytes from mouse small intestine. IV. Investigation of the proliferative capacity of IEL using phorbol ester and calcium ionophore.小鼠小肠上皮内淋巴细胞的功能特性。IV. 使用佛波酯和钙离子载体研究上皮内淋巴细胞的增殖能力。
Immunology. 1989 Mar;66(3):398-403.
2
Human intraepithelial lymphocytes.人上皮内淋巴细胞
Springer Semin Immunopathol. 1990;12(2-3):165-90. doi: 10.1007/BF00197504.

本文引用的文献

1
Natural killer activity of gut mucosal lymphoid cells in mice.小鼠肠道黏膜淋巴细胞的自然杀伤活性
Eur J Immunol. 1981 Nov;11(11):919-22. doi: 10.1002/eji.1830111112.
2
Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies.大鼠小肠上皮内、固有层和派尔集合淋巴结淋巴细胞：根据免疫球蛋白标记物和单克隆抗体受体进行分离与特性鉴定
Immunology. 1982 Apr;45(4):775-83.
3
Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract.人类胃肠道上皮内淋巴细胞的免疫组织学特征
Gut. 1981 Mar;22(3):169-76. doi: 10.1136/gut.22.3.169.
4
Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine.从小鼠小肠上皮和固有层制备及纯化淋巴细胞。
Gut. 1981 Jun;22(6):481-8. doi: 10.1136/gut.22.6.481.
5
Cytotoxic T cells in small intestine epithelial, lamina propria and lung lymphocytes.小肠上皮、固有层和肺淋巴细胞中的细胞毒性T细胞。
Immunology. 1981 Oct;44(2):367-71.
6
Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies.利用单克隆抗体对人小肠黏膜淋巴细胞进行免疫组织学和免疫电子显微镜特征分析。
J Immunol. 1983 Jun;130(6):2615-22.
7
Functional properties of lymphocytes isolated from murine small intestinal epithelium.从小鼠小肠上皮分离的淋巴细胞的功能特性。
Immunology. 1984 Jul;52(3):501-9.
8
Invasion of collagen gels by mouse lymphoid cells.小鼠淋巴细胞对胶原凝胶的侵袭。
Immunology. 1984 Feb;51(2):259-68.
9
Abnormal migration of T lymphocyte clones.T淋巴细胞克隆的异常迁移。
J Immunol. 1982 May;128(5):2134-6.
10
Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice.抗原致敏小鼠肠道黏膜中细胞毒性效应细胞的非特异性募集。
J Exp Med. 1984 Dec 1;160(6):1931-6. doi: 10.1084/jem.160.6.1931.

小鼠小肠上皮内淋巴细胞的功能特性。III. 上皮内淋巴细胞无法诱导全身性移植物抗宿主反应是由于其在体内无法迁移。

Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.

作者信息

Baca M E, Mowat A M, MacKenzie S, Parrott D M

机构信息

Department of Bacteriology and Immunology, Western Infirmary, Glasgow.

出版信息

Gut. 1987 Oct;28(10):1267-74. doi: 10.1136/gut.28.10.1267.

DOI:10.1136/gut.28.10.1267
PMID:3500097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433440/
Abstract

In this study we have investigated whether addition of bone marrow accessory cells or concurrent administration of recombinant IL-2 would allow intraepithelial lymphocytes (IEL) to induce a systemic, lethal GvHR in irradiated hosts. In addition we have studied the ability of IEL to migrate into lymphoid tissues after intravenous injection and compared this with their locomotor capacity in vitro.

摘要

在本研究中，我们调查了添加骨髓辅助细胞或同时给予重组白细胞介素-2是否能使上皮内淋巴细胞（IEL）在受辐照宿主中诱导全身性致死性移植物抗宿主反应（GvHR）。此外，我们研究了IEL静脉注射后迁移至淋巴组织的能力，并将其与它们在体外的运动能力进行了比较。