小肠上皮、固有层和肺淋巴细胞中的细胞毒性T细胞。
Cytotoxic T cells in small intestine epithelial, lamina propria and lung lymphocytes.
作者信息
Davies M D, Parrott D M
出版信息
Immunology. 1981 Oct;44(2):367-71.
Abstract
We have examined the development of specific cytotoxic T-cell activity in the lungs and the epithelium and lamina propria of the small intestine following tumour cell inoculation by subcutaneous or intraperitoneal routes. After an intraperitoneal injection of tumour cells, large amounts of cytotoxic activity are detectable in the lungs and lamina propria. In comparison, the epithelial lymphocytes of the small intestine display low cytotoxic activity. After a subcutaneous injection, little cytotoxicity is detectable except in the lungs and the development of such cytotoxicity has a much shorter time course compared with that induced by an intraperitoneal inoculation of tumour cells. The data indicate a marked difference in the functional capacity of lymphocytes from the epithelium and lamina propria of the small intestine.
摘要
我们研究了通过皮下或腹腔途径接种肿瘤细胞后，肺以及小肠上皮和固有层中特异性细胞毒性T细胞活性的发展情况。腹腔注射肿瘤细胞后，在肺和固有层中可检测到大量细胞毒性活性。相比之下，小肠上皮淋巴细胞的细胞毒性活性较低。皮下注射后，除肺之外几乎检测不到细胞毒性，且与腹腔接种肿瘤细胞所诱导的细胞毒性相比，这种细胞毒性的发展过程要短得多。这些数据表明小肠上皮和固有层淋巴细胞的功能能力存在显著差异。
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本文引用的文献
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