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具有拥挤效应的冠状病毒病动力学分析及疫苗接种:对第三种毒株的研究

Dynamical analysis of coronavirus disease with crowding effect, and vaccination: a study of third strain.

作者信息

Raza Ali, Rafiq Muhammad, Awrejcewicz Jan, Ahmed Nauman, Mohsin Muhammad

机构信息

Department of Mathematics, Government Maulana Zafar Ali Khan Graduate College Wazirabad, Punjab Higher Education Department (PHED), Lahore, 54000 Pakistan.

Department of Mathematics, Faculty of Sciences, University of Central Punjab, Lahore, 54500 Pakistan.

出版信息

Nonlinear Dyn. 2022;107(4):3963-3982. doi: 10.1007/s11071-021-07108-5. Epub 2022 Jan 4.

Abstract

Countries affected by the coronavirus epidemic have reported many infected cases and deaths based on world health statistics. The crowding factor, which we named "crowding effects," plays a significant role in spreading the diseases. However, the introduction of vaccines marks a turning point in the rate of spread of coronavirus infections. Modeling both effects is vastly essential as it directly impacts the overall population of the studied region. To determine the peak of the infection curve by considering the third strain, we develop a mathematical model (susceptible-infected-vaccinated-recovered) with reported cases from August 01, 2021, till August 29, 2021. The nonlinear incidence rate with the inclusion of both effects is the best approach to analyze the dynamics. The model's positivity, boundedness, existence, uniqueness, and stability (local and global) are addressed with the help of a reproduction number. In addition, the strength number and second derivative Lyapunov analysis are examined, and the model was found to be asymptotically stable. The suggested parameters efficiently control the active cases of the third strain in Pakistan. It was shown that a systematic vaccination program regulates the infection rate. However, the crowding effect reduces the impact of vaccination. The present results show that the model can be applied to other countries' data to predict the infection rate.

摘要

根据世界卫生统计数据,受新冠疫情影响的国家报告了许多感染病例和死亡情况。我们称之为“拥挤效应”的人群聚集因素在疾病传播中起着重要作用。然而,疫苗的引入标志着新冠病毒感染传播速度的一个转折点。对这两种效应进行建模至关重要,因为它直接影响所研究地区的总人口。为了通过考虑第三种毒株来确定感染曲线的峰值,我们利用2021年8月1日至2021年8月29日的报告病例建立了一个数学模型(易感-感染-接种-康复模型)。包含这两种效应的非线性发病率是分析动态变化的最佳方法。借助再生数来讨论模型的正性、有界性、存在性、唯一性和稳定性(局部和全局)。此外,还研究了强度数和二阶导数李雅普诺夫分析,发现该模型是渐近稳定的。所建议的参数有效地控制了巴基斯坦第三种毒株的活跃病例数。结果表明,系统的疫苗接种计划可以调节感染率。然而,拥挤效应会降低疫苗接种的效果。目前的结果表明,该模型可应用于其他国家的数据以预测感染率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca67/8726531/87cd15d69236/11071_2021_7108_Fig1_HTML.jpg

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