Molecular Endocrinology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Uttarakhand 247667, India.
Current address: Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, Uttarakhand 249405.
Int J Biol Sci. 2022 Jan 1;18(2):675-692. doi: 10.7150/ijbs.63721. eCollection 2022.
Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.
卵泡刺激素(FSH)及其受体(FSHR)已被报道负责多种生理功能和癌症。干细胞和癌症干细胞对 FSH-FSHR 系统的反应使得 FSH 及其受体在癌症生物学中的功能更加有趣。本综述包括 FSH-FSHR 信号在正常生理、性腺干细胞、癌细胞中的综合信息,以及利用 FSH-FSHR 系统作为抗癌治疗靶点的潜在选择。