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促卵泡生成素对婴儿血管瘤干细胞增殖和凋亡的影响。

Effects of follicle-stimulating hormone on the proliferation and apoptosis of infantile hemangioma stem cells.

作者信息

Hong Zhiqian, Kuang Junxi, Guo Yadong, Zhou Guanglin, Zhu Zhengjie, Jiang Lewen

机构信息

Longgang District Maternity & Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, Guangdong, China.

Department of Cardiovascular Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

出版信息

Biochem Biophys Rep. 2023 Sep 30;35:101551. doi: 10.1016/j.bbrep.2023.101551. eCollection 2023 Sep.

DOI:10.1016/j.bbrep.2023.101551
PMID:37823006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10562740/
Abstract

OBJECTIVE

To investigate the effects of different concentrations of follicle-stimulating hormone (FSH) on the proliferation and apoptosis of human hemangioma stem cells, it will provide a basis for studying the mechanism of FSH in treating hemangioma.

METHODS

Hemangioma specimens were collected from the Longgang District Maternity & Child Healthcare Hospital of Shenzhen City. Hemangioma stem cells were treated with different concentrations of FSH. Cell viability was detected by CCK8 method and cell apoptosis was analyzed by flow cytometry.

RESULTS

Hemangioma stem cells (HemSCs) were extracted from fresh tissue of infantile hemangioma by the CD133 immunomagnetic bead method. Under the influence of FSH at different concentrations (0, 100, 1000 IU/L), the cell viability of hemangioma stem cells increased significantly in a concentration-dependent manner ( < 0.05). At the same time, the apoptosis of hemangioma stem cells decreased with increasing concentrations of follicle-stimulating hormone ( < 0.05). Specifically, 1000 IU/L FSH significantly promoted the proliferation of hemangioma stem cells and inhibited their apoptosis.

CONCLUSION

High concentration of follicle-stimulating hormone can maintain the growth of hemangioma by promoting the proliferation and inhibiting the apoptosis of hemangioma stem cells.

摘要

目的

探讨不同浓度促卵泡生成素（FSH）对人血管瘤干细胞增殖和凋亡的影响，为研究FSH治疗血管瘤的机制提供依据。

方法

收集深圳市龙岗区妇幼保健院的血管瘤标本。用不同浓度的FSH处理血管瘤干细胞。采用CCK8法检测细胞活力，流式细胞术分析细胞凋亡情况。

结果

采用CD133免疫磁珠法从婴幼儿血管瘤新鲜组织中提取血管瘤干细胞。在不同浓度（0、100、1000 IU/L）FSH作用下，血管瘤干细胞的细胞活力呈浓度依赖性显著增加（P<0.05）。同时，随着促卵泡生成素浓度的增加，血管瘤干细胞的凋亡减少（P<0.05）。具体而言，1000 IU/L FSH显著促进血管瘤干细胞的增殖并抑制其凋亡。

结论

高浓度促卵泡生成素可通过促进血管瘤干细胞增殖、抑制其凋亡来维持血管瘤生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/7062cf450207/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/3e561073b370/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/ed88847d6a42/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/bb28cc053a86/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/7062cf450207/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/3e561073b370/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/ed88847d6a42/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/bb28cc053a86/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6b/10562740/7062cf450207/gr4.jpg

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本文引用的文献

1
Management of infantile hemangiomas: Recent advances.婴儿血管瘤的管理：最新进展
Front Oncol. 2022 Nov 29;12:1064048. doi: 10.3389/fonc.2022.1064048. eCollection 2022.
2
Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer and .卵泡刺激素促进子宫内膜癌的发展和.
Int J Environ Res Public Health. 2022 Nov 20;19(22):15344. doi: 10.3390/ijerph192215344.
3
Protective Effect of Follicle-Stimulating Hormone on DNA Damage of Chicken Follicular Granulosa Cells by Inhibiting CHK2/p53.卵泡刺激素通过抑制 CHK2/p53 对鸡卵泡颗粒细胞 DNA 损伤的保护作用。
Cells. 2022 Apr 11;11(8):1291. doi: 10.3390/cells11081291.
4
Hemangioma Endothelial Cells and Hemangioma Stem Cells in Infantile Hemangioma.婴幼儿血管瘤中的血管内皮细胞和血管瘤干细胞。
Ann Plast Surg. 2022 Feb 1;88(2):244-249. doi: 10.1097/SAP.0000000000002835.
5
Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.卵泡刺激素及其受体在生殖和干细胞及癌症干细胞中的概述。
Int J Biol Sci. 2022 Jan 1;18(2):675-692. doi: 10.7150/ijbs.63721. eCollection 2022.
6
Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma: A Randomized Clinical Trial.纳多洛尔与普萘洛尔治疗婴儿血管瘤的非劣效性和安全性：一项随机临床试验。
JAMA Pediatr. 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565.
7
Infantile hemangioma. Part 2: Management.婴儿血管瘤。第2部分：管理
J Am Acad Dermatol. 2021 Dec;85(6):1395-1404. doi: 10.1016/j.jaad.2021.08.020. Epub 2021 Aug 19.
8
Follicle-stimulating hormone (FSH) levels prior to prostatectomy are not related to long-term oncologic or cardiovascular outcomes for men with prostate cancer.前列腺切除术之前的卵泡刺激素（FSH）水平与前列腺癌男性的长期肿瘤学或心血管结局无关。
Asian J Androl. 2022 Jan-Feb;24(1):21-25. doi: 10.4103/aja.aja_58_21.
9
Update on infantile hemangioma.婴儿血管瘤的最新进展。
Clin Exp Pediatr. 2021 Nov;64(11):559-572. doi: 10.3345/cep.2020.02061. Epub 2021 May 26.
10
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Mol Ther Nucleic Acids. 2021 Jan 26;23:1334-1344. doi: 10.1016/j.omtn.2021.01.022. eCollection 2021 Mar 5.