Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, United States.
Rebecca and John Moore Comprehensive Cancer Center, University of California San Diego, San Diego, CA, United States.
Front Immunol. 2021 Dec 22;12:783780. doi: 10.3389/fimmu.2021.783780. eCollection 2021.
Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear receptor family, have been extensively studied for their roles in development, differentiation, and homeostatic processes. In the recent past, there has been substantial interest in understanding and defining the functions of PPARs and their agonists in regulating innate and adaptive immune responses as well as their pharmacologic potential in combating acute and chronic inflammatory disease. In this review, we focus on emerging evidence of the potential roles of the PPAR subtypes in macrophage biology. We also discuss the roles of dual and pan PPAR agonists as modulators of immune cell function, microbial infection, and inflammatory diseases.
细胞富含核受体，核受体作为配体调控转录因子。过氧化物酶体增殖物激活受体 (PPAR) 是核受体家族的成员，因其在发育、分化和动态平衡过程中的作用而得到广泛研究。最近，人们对理解和定义 PPAR 及其激动剂在调节先天和适应性免疫反应中的作用以及它们在对抗急性和慢性炎症性疾病方面的药理潜力产生了浓厚的兴趣。在这篇综述中，我们重点介绍了 PPAR 亚型在巨噬细胞生物学中的潜在作用的新证据。我们还讨论了双重和全 PPAR 激动剂作为免疫细胞功能、微生物感染和炎症性疾病调节剂的作用。
