心力衰竭患者的替代补体途径被激活，而没有相应的末端补体途径激活。
The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure.
机构信息
Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
出版信息
Front Immunol. 2021 Dec 24;12:800978. doi: 10.3389/fimmu.2021.800978. eCollection 2021.
OBJECTIVE
Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these patients. We hypothesized that plasma levels of FB and C3bBbP would be associated with disease severity and survival in patients with HF.
METHODS
We analyzed plasma levels of FB, C3bBbP, and terminal C5b-9 complement complex (TCC) in 343 HF patients and 27 healthy controls.
RESULTS
Compared with controls, patients with HF had elevated levels of circulating FB (1.6-fold, p < 0.001) and C3bBbP (1.3-fold, p < 0.001). In contrast, TCC, reflecting the terminal pathway, was not significantly increased (p = 0.15 vs controls). FB was associated with NT-proBNP, troponin, eGFR, and i.e., C-reactive protein. FB, C3bBbP and TCC were not associated with mortality in HF during a mean follow up of 4.3 years.
CONCLUSION
Our findings suggest that in patients with HF, the alternative pathway is activated. However, this is not accompanied by activation of the terminal pathway.
目的
补体系统失调已在心力衰竭（HF）患者中描述。然而，替代途径的数据很少，并且尚不清楚这些患者的因子 B（FB）和 C3 转化酶 C3bBbP 水平是否升高。我们假设 FB 和 C3bBbP 的血浆水平与 HF 患者的疾病严重程度和生存相关。
方法
我们分析了 343 例 HF 患者和 27 例健康对照者的 FB、C3bBbP 和末端 C5b-9 补体复合物（TCC）的血浆水平。
结果
与对照组相比，HF 患者的循环 FB（1.6 倍，p<0.001）和 C3bBbP（1.3 倍，p<0.001）水平升高。相比之下，反映末端途径的 TCC 没有明显增加（p=0.15 与对照组相比）。FB 与 NT-proBNP、肌钙蛋白、eGFR 和 C 反应蛋白有关。在平均 4.3 年的随访中，FB、C3bBbP 和 TCC 与 HF 患者的死亡率无关。
结论
我们的发现表明，在 HF 患者中，替代途径被激活。然而，这并不伴随着末端途径的激活。
Zotero 插件