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耳针治疗α-半乳糖哺乳动物产品过敏的成功案例:病例系列

Successful Treatment for Alpha Gal Mammal Product Allergy Using Auricular Acupuncture: A Case Series.

作者信息

Bernal Mateo, Huecker Martin, Shreffler Jacob, Mittel Olivia, Mittel Joseph, Soliman Nader

机构信息

Louisville Community Supported Acupuncture, Louisville, KY, USA.

Department of Emergency Medicine, University of Louisville School of Medicine, Louisville, KY, USA.

出版信息

Med Acupunct. 2021 Oct 1;33(5):343-348. doi: 10.1089/acu.2021.0010. Epub 2021 Oct 18.

DOI:10.1089/acu.2021.0010
PMID:35003502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8729907/
Abstract

Alpha gal syndrome (AGS) is an acquired allergy to mammalian products correlates with a tick bite(s) that appears to cause immune sensitization to an oligosaccharide in meat. Most publications on AGS describe no management other than avoidance of the offending agent(s). The objective of this study is to describe 2 populations of subjects who underwent Soliman Auricular Allergy Treatment (SAAT) for significant AGS meat and/or dairy allergy. We performed a retrospective review of subjects treated at 2 different medical clinics that apply the same method of auricular acupuncture (SAAT) to AGS patients. A total of 137 patients presented to the 2 sites included in this study. The majority of patients were mammal product eaters before AGS; however, at the time of treatment only 7.3% of individuals ( = 10) actively consumed mammal products. Most subjects were reactive to beef ( = 135) and dairy ( = 95). The most common organ system involved in prior allergic reactions associated with AGS were gastrointestinal ( = 82, 59.9%) and dermatologic ( = 61, 44.5%). For those individuals with available outcome data on SAAT effectiveness ( = 126), 121 (96%) patients indicated that their symptoms were in remission after SAAT. Five individuals indicated that their symptoms were not in remission. Eleven individuals were unsure of treatment response or unable to be reached for follow-up. The SAAT method showed effectiveness in the large majority of patients. No adverse reactions were noted as a result of auricular acupuncture. This alternative medicine approach to AGS management should be further studied in prospective trials with laboratory confirmation both before and after the procedure. This low-risk treatment shows promise in treating a medical condition that causes distress in an increasing number of patients.

摘要

α-半乳糖综合征(AGS)是一种对哺乳动物制品的后天性过敏,与蜱虫叮咬相关,蜱虫叮咬似乎会导致对肉类中一种寡糖产生免疫致敏。大多数关于AGS的出版物除了建议避免接触致病因素外,未描述其他治疗方法。本研究的目的是描述两组因严重的AGS肉类和/或乳制品过敏而接受索利曼耳穴过敏治疗(SAAT)的受试者群体。我们对在两家不同医疗诊所接受治疗的受试者进行了回顾性研究,这两家诊所对AGS患者采用相同的耳针疗法(SAAT)。本研究共纳入了在这两个地点就诊的137名患者。大多数患者在患AGS之前食用哺乳动物制品;然而,在治疗时,只有7.3%的个体(n = 10)仍在积极食用哺乳动物制品。大多数受试者对牛肉(n = 135)和乳制品(n = 95)有反应。与AGS相关的既往过敏反应中最常累及的器官系统是胃肠道(n = 82,59.9%)和皮肤(n = 61,44.5%)。对于那些有SAAT疗效可用结果数据的个体(n = 126),121名(96%)患者表示SAAT治疗后症状缓解。5名个体表示症状未缓解。11名个体不确定治疗反应或无法联系到进行随访。SAAT方法在绝大多数患者中显示出有效性。未观察到耳针治疗引起的不良反应。这种用于AGS治疗的替代医学方法应在前瞻性试验中进一步研究,并在治疗前后进行实验室确认。这种低风险治疗方法在治疗一种使越来越多患者感到痛苦的疾病方面显示出前景。

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本文引用的文献

1
Tick exposures and alpha-gal syndrome: A systematic review of the evidence.蜱虫暴露与 alpha-gal 综合征:证据的系统评价。
Ticks Tick Borne Dis. 2021 May;12(3):101674. doi: 10.1016/j.ttbdis.2021.101674. Epub 2021 Jan 27.
2
Alpha-gal syndrome: challenges to understanding sensitization and clinical reactions to alpha-gal.α-半乳糖综合征:理解对 α-半乳糖致敏和临床反应的挑战。
Expert Rev Mol Diagn. 2020 Sep;20(9):905-911. doi: 10.1080/14737159.2020.1792781. Epub 2020 Jul 14.
3
Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients.α-半乳糖苷综合征的诊断与管理:2500 例患者的经验教训。
Expert Rev Clin Immunol. 2020 Jul;16(7):667-677. doi: 10.1080/1744666X.2020.1782745. Epub 2020 Jul 8.
4
Clinical and Serological Characterization of the α-Gal Syndrome-Importance of Atopy for Symptom Severity in a European Cohort.α-半乳糖综合征的临床和血清学特征——欧洲队列中特应性对症状严重程度的重要性
J Allergy Clin Immunol Pract. 2020 Jun;8(6):2027-2034.e2. doi: 10.1016/j.jaip.2020.02.016. Epub 2020 Mar 3.
5
Alpha-Gal and Cross-Reactive Carbohydrate Determinants in the N-Glycans of Salivary Glands in the Lone Star Tick, .孤星蜱唾液腺 N-聚糖中的α-半乳糖和交叉反应性碳水化合物决定簇
Vaccines (Basel). 2020 Jan 9;8(1):18. doi: 10.3390/vaccines8010018.
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No Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity.绝非虚言:一例与水牛肉敏感性相关的α-半乳糖综合征病例。
Allergy Rhinol (Providence). 2019 Dec 8;10:2152656719893366. doi: 10.1177/2152656719893366. eCollection 2019 Jan-Dec.
7
Prevalence and Impact of Type I Sensitization to Alpha-Gal in Patients Consulting an Allergy Unit.在过敏科就诊患者中 I 型α-半乳糖过敏的流行情况及影响。
Int Arch Allergy Immunol. 2020;181(2):119-127. doi: 10.1159/000503966. Epub 2019 Dec 5.
8
Bracing for the Worst - Range Expansion of the Lone Star Tick in the Northeastern United States.为最坏情况做准备——美国东北部孤星蜱的分布范围扩张
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Allergol Immunopathol (Madr). 2020 May-Jun;48(3):251-258. doi: 10.1016/j.aller.2019.07.004. Epub 2019 Nov 11.
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