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复发性奥吉尔维综合征作为α-半乳糖综合征（AGS）的一种可能表现需要手术治疗：一例病例报告。

Recurrent Ogilvie Syndrome as a Possible Manifestation of Alpha-Gal Syndrome (AGS) Requiring Surgical Management: A Case Report.

作者信息

Dai Jean, Obokhare Izi

机构信息

General Surgery, Texas Tech University Health Sciences Center (TTUHSC) School of Medicine, Amarillo, USA.

出版信息

Cureus. 2024 Apr 30;16(4):e59357. doi: 10.7759/cureus.59357. eCollection 2024 Apr.

DOI:10.7759/cureus.59357
PMID:38817474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11138235/
Abstract

We present a case of a male in his 60s with a history of alpha-gal syndrome (AGS) who presented with recurrent acute colonic pseudo-obstruction, also known as Ogilvie syndrome, and underwent surgical treatment for life-limiting symptoms of colonic distention, constipation, and abdominal pain. Prior to surgery, he was hospitalized multiple times after beef consumption and was diagnosed with Ogilvie syndrome, requiring a colonoscopy with rectal tube placement for symptom resolution. He later underwent a robotic subtotal colectomy with ileocolic anastomosis. Follow-up visits showed improvement in symptoms of constipation and abdominal distention. This case highlights that AGS may lead to severe manifestations, such as recurrent Ogilvie syndrome. Due to the increasing prevalence of AGS and limited data on disease course, further research is needed to determine symptom manifestations and the potential utility of surgery in management.

摘要

我们报告了一例60多岁男性，有α-半乳糖综合征（AGS）病史，该患者出现复发性急性结肠假性梗阻（又称奥吉尔维综合征），并因结肠扩张、便秘和腹痛等危及生命的症状接受了手术治疗。术前，他在食用牛肉后多次住院，被诊断为奥吉尔维综合征，需要进行结肠镜检查并放置直肠管以缓解症状。他后来接受了机器人辅助次全结肠切除术并进行回结肠吻合术。随访显示便秘和腹胀症状有所改善。该病例表明，AGS可能导致严重表现，如复发性奥吉尔维综合征。由于AGS的患病率不断上升且关于病程的数据有限，需要进一步研究以确定症状表现以及手术在治疗中的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/bb12592dbc03/cureus-0016-00000059357-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/2c206bab8802/cureus-0016-00000059357-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/9e91088cb6b3/cureus-0016-00000059357-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/fc5d25827f4c/cureus-0016-00000059357-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/84b639d3a611/cureus-0016-00000059357-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/ec9b485d2e79/cureus-0016-00000059357-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/972ad148ddf3/cureus-0016-00000059357-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/59f16d103cd0/cureus-0016-00000059357-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/69b589bf153b/cureus-0016-00000059357-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/bb12592dbc03/cureus-0016-00000059357-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/2c206bab8802/cureus-0016-00000059357-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/9e91088cb6b3/cureus-0016-00000059357-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/fc5d25827f4c/cureus-0016-00000059357-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/84b639d3a611/cureus-0016-00000059357-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/ec9b485d2e79/cureus-0016-00000059357-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/972ad148ddf3/cureus-0016-00000059357-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/59f16d103cd0/cureus-0016-00000059357-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/69b589bf153b/cureus-0016-00000059357-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49da/11138235/bb12592dbc03/cureus-0016-00000059357-i09.jpg

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本文引用的文献

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Geographic Distribution of Suspected Alpha-gal Syndrome Cases - United States, January 2017-December 2022.疑似α-半乳糖综合征病例的地理分布-美国，2017 年 1 月至 2022 年 12 月。
MMWR Morb Mortal Wkly Rep. 2023 Jul 28;72(30):815-820. doi: 10.15585/mmwr.mm7230a2.
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AGA Clinical Practice Update on Alpha-Gal Syndrome for the GI Clinician: Commentary.AGA 临床实践更新：胃肠病医师须知的 Alpha-Gal 综合征
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The α-Gal Syndrome and Potential Mechanisms.
α-半乳糖综合征及其潜在机制。
Front Allergy. 2021 Dec 16;2:783279. doi: 10.3389/falgy.2021.783279. eCollection 2021.
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Ogilvie's syndrome-is there a cutoff diameter to proceed with upfront surgery?奥格利夫（Ogilvie）综合征——是否存在直接进行手术的临界直径？
Langenbecks Arch Surg. 2022 May;407(3):1173-1182. doi: 10.1007/s00423-021-02407-2. Epub 2022 Jan 12.
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Successful Treatment for Alpha Gal Mammal Product Allergy Using Auricular Acupuncture: A Case Series.耳针治疗α-半乳糖哺乳动物产品过敏的成功案例：病例系列
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Allergy to Mammalian Meat Linked to Alpha-Gal Syndrome Potentially After Tick Bite in the Amazon: A Case Series.在亚马逊地区被蜱虫叮咬后，哺乳动物肉类过敏可能与α-半乳糖综合征有关：病例系列。
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'Doc, will I ever eat steak again?': diagnosis and management of alpha-gal syndrome.“医生，我还能再吃牛排吗？”：α-半乳糖胺综合征的诊断与治疗。
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Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers.孤立星蜱叮咬与 α-半乳糖致敏增加之间的关联：来自户外工作者前瞻性队列研究的证据。
Parasit Vectors. 2020 Sep 14;13(1):470. doi: 10.1186/s13071-020-04343-4.
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