Fazel Mojtaba, Afshari Elham, Jarrahi Neda
Department of Emergency Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Pediatric Dentistry, School of Dentistry, Golestan university of Medical Sciences, Gorgan, Iran.
Dent Res J (Isfahan). 2021 Nov 22;18:98. doi: 10.4103/1735-3327.330879. eCollection 2021.
Tricho-dento-osseous syndrome (TDO) is a rare autosomal dominant disorder with complete penetrance. Common clinical features include abnormalities of hair, teeth, and skull. Dental management of TDO patients is quite challenging in terms of existing dental and skeletal problems. The current article presents a 12-year-old girl suffering TDO, followed by a review on the published literature pertaining to the dental management of TDO patients. Patient history included, rejected corneal transplantation, stone-forming kidneys, and several previous dental treatments. She was noted to have signs of mandibular prognatia, frontal bossing of the skull, mild bilateral tibial bowing, microstomia, and labial fissures. Dental findings included severe generalized enamel defects, discolored teeth, microdontia, anterior open-bite, posterior cross-bite, deep periodontal pockets, hyperplastic inflamed gingiva, taurodontism of permanent molars, dental periapical radiolucencies, and missing teeth. She was the only child of healthy, nonconsanguineous parents with no familial history of similar congenital syndrome or dental abnormalities. A treatment plan was established based on medical/dental history and findings, using a team-based approach. This article emphasizes the importance of a multidisciplinary approach for the dental management of patients suffering TDO.
毛发-牙齿-骨综合征（TDO）是一种罕见的常染色体显性疾病，具有完全外显率。常见的临床特征包括毛发、牙齿和颅骨异常。就现有的牙齿和骨骼问题而言，TDO患者的牙科治疗颇具挑战性。本文介绍了一名患有TDO的12岁女孩，随后对已发表的有关TDO患者牙科治疗的文献进行了综述。患者病史包括角膜移植被拒、肾结石形成以及之前的多次牙科治疗。她被发现有下颌前突、颅骨额部隆起、双侧胫骨轻度弓形、小口畸形和唇裂等体征。牙科检查结果包括严重的广泛性釉质缺陷、牙齿变色、小牙、前牙开颌、后牙反颌、深牙周袋、增生性炎症牙龈、恒牙磨牙根分叉异常、牙齿根尖周透射区和牙齿缺失。她是健康非近亲父母的独生女，家族中无类似先天性综合征或牙齿异常的病史。根据病史和检查结果，采用团队协作的方法制定了治疗计划。本文强调了多学科方法在TDO患者牙科治疗中的重要性。
