使用紧凑型光纤探头在短源探测器间距下通过空间分辨漫反射进行光学特性恢复。
Optical property recovery with spatially-resolved diffuse reflectance at short source-detector separations using a compact fiber-optic probe.
作者信息
Bridger Karina G, Roccabruna Jacob R, Baran Timothy M
机构信息
Department of Biomedical Engineering, University of Rochester, 201 Robert B. Goergen Hall, P.O. Box 270168, Rochester, NY 14627, USA.
Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave, Box 648, Rochester, NY 14642, USA.
出版信息
Biomed Opt Express. 2021 Nov 9;12(12):7388-7404. doi: 10.1364/BOE.443332. eCollection 2021 Dec 1.
Abstract
We describe a compact fiber-optic probe (2 mm outside diameter) that utilizes spatially-resolved diffuse reflectance for tissue optical property recovery. Validation was performed in phantoms containing Intralipid 20% as scatterer, and methylene blue (MB), MnTPPS, and/or India ink as absorbers. Over a range of conditions, the reduced scattering coefficient was recovered with a root mean square error (RMSE) of 0.86-2.7 cm (average error = 3.8%). MB concentration was recovered with RMSE = 0.26-0.52 µM (average error = 15.0%), which did not vary with inclusion of MnTPPS (p=0.65). This system will be utilized to determine optical properties in human abscesses, in order to generate treatment plans for photodynamic therapy.
摘要
我们描述了一种紧凑型光纤探头（外径2毫米），它利用空间分辨漫反射来恢复组织光学特性。在含有20% Intralipid作为散射体以及亚甲蓝（MB）、锰四苯基卟啉（MnTPPS）和/或印度墨水作为吸收体的模型中进行了验证。在一系列条件下，恢复的约化散射系数的均方根误差（RMSE）为0.86 - 2.7厘米（平均误差 = 3.8%）。MB浓度的恢复RMSE = 0.26 - 0.52微摩尔（平均误差 = 15.0%），其不受MnTPPS的影响（p = 0.65）。该系统将用于确定人体脓肿的光学特性，以便制定光动力治疗的治疗方案。
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