El Goundali Khaddouj, Chebabe Milouda, Elkhoudri Noureddine, Hilali Abderraouf
Laboratory of Health Sciences and Technologies, Settat, Morocco.
Higher Institute of Health Sciences, Hassan First University of Settat, Settat, Morocco.
J Res Health Sci. 2025 Apr 1;25(2):e00646. doi: 10.34172/jrhs.2025.181.
The prevalence of non-communicable diseases (NCDs) represents a significant global health challenge, accounting for 71% of global deaths. This concern is also widespread in Morocco. Consanguinity, common in Arab and Muslim regions, could influence the genetic predisposition to these diseases. This study aimed to explore the impact of consanguineous marriage (CM) on predisposition to these chronic illnesses among the populace in Settat province, Morocco, concerning prevalent NCDs. A cross-sectional study.
This study was conducted in Settat, Morocco, from April to October 2021 and included 453 married women aged 18 and above. Participants were selected from rural and urban health centers using a two-stage sampling method. The data were collected through structured interviews using a validated questionnaire. Statistical analyses with SPSS 26 assessed associations between consanguinity and NCDs in respondents and their descendants using odds ratios (ORs) and 95% confidence intervals.
The participants had a mean age of 38.04 years, with 35% residing in rural areas and 26.7% having a CM. The results indicated that individuals with consanguineous ancestors have a greater risk of contracting NCDs, such as cardiovascular diseases (CVDs) (OR=2.047, =0.005), diabetes (OR=1.988, =0.009), asthma (OR=2.069, =0.036), chronic kidney disease (CKD) (OR=1.732, =0.045), and cancer (OR=1.646, =0.1), compared to those with non-consanguineous parents.
It is essential to integrate the harmful effects of consanguinity on future generations' health into public health policy through genetic counseling, testing, screening, and awareness programs.
非传染性疾病（NCDs）的流行是一项重大的全球健康挑战，占全球死亡人数的71%。这种情况在摩洛哥也很普遍。近亲结婚在阿拉伯和穆斯林地区很常见，可能会影响这些疾病的遗传易感性。本研究旨在探讨近亲结婚（CM）对摩洛哥塞塔特省民众中这些慢性病易感性的影响，涉及常见的非传染性疾病。一项横断面研究。
本研究于2021年4月至10月在摩洛哥塞塔特进行，纳入了453名18岁及以上的已婚女性。参与者采用两阶段抽样方法从农村和城市卫生中心选取。通过使用经过验证的问卷进行结构化访谈收集数据。使用SPSS 26进行统计分析，通过比值比（ORs）和95%置信区间评估近亲结婚与受访者及其后代非传染性疾病之间的关联。
参与者的平均年龄为38.04岁，35%居住在农村地区，26.7%有近亲结婚情况。结果表明，与父母非近亲结婚的人相比，有近亲祖先的个体患非传染性疾病的风险更高，如心血管疾病（CVDs）（OR = 2.047，P = 0.005）、糖尿病（OR = 1.988，P = 0.009）、哮喘（OR = 2.069，P = 0.036）、慢性肾脏病（CKD）（OR = 1.732，P = 0.045）和癌症（OR = 1.646，P = 0.1）。
通过遗传咨询、检测、筛查和提高认识计划，将近亲结婚对后代健康的有害影响纳入公共卫生政策至关重要。
