Holman B L, Hill T C, Polak J F, Lee R G, Royal H D, O'Leary D H
Arch Neurol. 1984 Oct;41(10):1060-3. doi: 10.1001/archneur.1984.04050210058015.
Two amines, N-isopropyl p-iodoamphetamine and N,N,N'-trimethyl-N'-[2-hydroxyl-3-methyl-5-iodobenzyl]-1,3-prop anediamine, have been labeled with iodine 123. The brain uptake of these radioactive tracers is proportional to cerebral blood flow. These tracers are retained in the brain for a sufficiently long time so that imaging can be performed with standard, readily available instrumentation. Transaxial tomography with amines is useful in acute cerebral infarction, in which the x-ray computed tomographic scan may be normal for several days after onset of symptoms while the uptake of radioisotope-labeled amines will be altered immediately after the onset of the stroke. It is also useful in examining patients with cerebral vascular disease and in the preoperative examination of patients with partial epilepsy.
两种胺类化合物，即N-异丙基对碘安非他明和N,N,N'-三甲基-N'-[2-羟基-3-甲基-5-碘苄基]-1,3-丙二胺，已用碘123进行了标记。这些放射性示踪剂在大脑中的摄取量与脑血流量成正比。这些示踪剂在大脑中保留的时间足够长，因此可以使用标准的、易于获得的仪器进行成像。用胺类化合物进行的横断面断层扫描在急性脑梗死中很有用，在急性脑梗死中，症状发作后的几天内X线计算机断层扫描可能正常，而放射性同位素标记的胺类化合物的摄取在中风发作后会立即改变。它在检查脑血管疾病患者和部分癫痫患者的术前检查中也很有用。
