Gong Fengying, Yang Yuchao, Wen Liangtao, Wang Congrong, Li Jingjun, Dai Jingxing
Department of Traditional Chinese Medicine, Nanfang Hospital of Southern Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Front Cell Dev Biol. 2021 Dec 24;9:781828. doi: 10.3389/fcell.2021.781828. eCollection 2021.
Cells and tissues in the human body are subjected to mechanical forces of varying degrees, such as tension or pressure. During tumorigenesis, physical factors, especially mechanical factors, are involved in tumor development. As lung tissue is influenced by movements associated with breathing, it is constantly subjected to cyclical stretching and retraction; therefore, lung cancer cells and lung cancer-associated fibroblasts (CAFs) are constantly exposed to mechanical load. Thus, to better explore the mechanisms involved in lung cancer progression, it is necessary to consider factors involved in cell mechanics, which may provide a more comprehensive analysis of tumorigenesis. The purpose of this review is: 1) to provide an overview of the anatomy and tissue characteristics of the lung and the presence of mechanical stimulation; 2) to summarize the role of mechanical stretching in the progression of lung cancer; and 3) to describe the relationship between mechanical stretching and the lung cancer microenvironment, especially CAFs.
人体中的细胞和组织会受到不同程度的机械力作用，如拉力或压力。在肿瘤发生过程中，物理因素，尤其是机械因素，参与肿瘤发展。由于肺组织受到与呼吸相关运动的影响，它不断受到周期性的拉伸和回缩；因此，肺癌细胞和肺癌相关成纤维细胞（CAFs）不断暴露于机械负荷之下。因此，为了更好地探究肺癌进展所涉及的机制，有必要考虑细胞力学相关因素，这可能会对肿瘤发生提供更全面的分析。本综述的目的是：1）概述肺的解剖结构、组织特征以及机械刺激的存在情况；2）总结机械拉伸在肺癌进展中的作用；3）描述机械拉伸与肺癌微环境，尤其是CAFs之间的关系。
