Wang Jay C, McKay Kenneth M, Sood Arjun B, Laíns Inês, Sobrin Lucia, Miller John B
Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA,
Clin Ophthalmol. 2018 Dec 31;13:95-105. doi: 10.2147/OPTH.S185468. eCollection 2019.
To characterize and compare choroidal neovascularization (CNV) secondary to white dot syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A).
This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. CNV area and vessel density (VD) were measured by three independent graders, and linear regression analysis was subsequently performed.
Three patients with multifocal choroiditis and panuveitis, one patient each with birdshot chorioretinopathy, presumed ocular histoplasmosis syndrome, and persistent placoid maculopathy, and eleven patients with AMD with sufficient image quality were included. CNV associated with WDS was significantly smaller than that secondary to AMD (0.56±0.32 vs 2.79±1.80 mm, =-2.22, =0.01), while no difference in VD was detected (0.46±0.09 vs 0.44±0.09, =0.02, =0.71).
CNV networks secondary to WDS appear to be smaller than those secondary to AMD but have similar VD. OCT-A is a powerful tool to investigate properties of CNV from various etiologies. Larger studies are needed for further characterization and understanding of CNV pathogenesis in inflammatory conditions.
使用光学相干断层扫描血管造影（OCT-A）对白点综合征（WDS）和年龄相关性黄斑变性（AMD）继发的脉络膜新生血管（CNV）进行特征描述和比较。
这是一项横断面研究，我们使用蔡司Angioplex OCT-A或Optovue AngioVue OCT-A对WDS和AMD继发CNV的患者进行成像。收集并分析相关的人口统计学和临床特征。由三名独立的分级人员测量CNV面积和血管密度（VD），随后进行线性回归分析。
纳入了3例多灶性脉络膜炎和全葡萄膜炎患者、1例鸟枪弹样脉络膜视网膜病变患者、1例疑似眼组织胞浆菌病综合征患者、1例持续性地图状黄斑病变患者以及11例图像质量足够的AMD患者。与WDS相关的CNV明显小于AMD继发的CNV（0.56±0.32 vs 2.79±1.80 mm，=-2.22，=0.01），而VD未检测到差异（0.46±0.09 vs 0.44±0.09，=0.02，=0.71）。
WDS继发的CNV网络似乎比AMD继发的小，但VD相似。OCT-A是研究各种病因引起的CNV特性的有力工具。需要进行更大规模的研究以进一步表征和理解炎症性疾病中CNV的发病机制。
