白细胞介素-2的三维结构

Three-dimensional structure of interleukin-2.

作者信息

Brandhuber B J, Boone T, Kenney W C, McKay D B

机构信息

Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309.

出版信息

Science. 1987 Dec 18;238(4834):1707-9. doi: 10.1126/science.3500515.

DOI:10.1126/science.3500515

PMID:3500515

Abstract

Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.

摘要

白细胞介素-2是一种参与调节免疫反应的效应蛋白；它已成为淋巴因子结构与功能研究的焦点。白细胞介素分子的三维结构已解析到3.0埃的分辨率。白细胞介素-2具有一种新颖的α螺旋三级结构，这表明该分子的一部分形成了一个结构支架，它是该分子受体结合面的基础。