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多伦多综合医院过渡性疼痛服务中心对术后患者的阿片类药物减量及疼痛管理

Opioid weaning and pain management in postsurgical patients at the Toronto General Hospital Transitional Pain Service.

作者信息

Clarke Hance, Azargive Saam, Montbriand Janice, Nicholls Judith, Sutherland Ainsley, Valeeva Liliya, Boulis Sherif, McMillan Kayla, Ladak Salima S J, Ladha Karim, Katznelson Rita, McRae Karen, Tamir Diana, Lyn Sheldon, Huang Alexander, Weinrib Aliza, Katz Joel

机构信息

Pain Research Unit, Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, Canada.

Department of Anesthesia, University of Toronto, Toronto, Canada.

出版信息

Can J Pain. 2018 Aug 20;2(1):236-247. doi: 10.1080/24740527.2018.1501669. eCollection 2018.

Abstract

BACKGROUND

The perioperative period provides a critical window to address opioid use, particularly in patients with a history of chronic pain and presurgical opioid use. The Toronto General Hospital Transitional Pain Service (TPS) was developed to address the issues of pain and opioid use after surgery.

AIMS

To provide program evaluation results from the TPS at the Toronto General Hospital highlighting opioid weaning rates and pain management of opioid-naïve and opioid-experienced surgical patients.

METHODS

Two hundred fifty-one high-risk TPS patients were dichotomized preoperatively as opioid naïve or opioid experienced. Outcomes included pain, opioid consumption, weaning rates, and psychosocial/medical comorbidities.

RESULTS

Six months postoperatively, pain and function were significantly improved. Opioid-naïve and opioid-experienced patients reduced consumption by 69% and 44%, respectively. Forty-six percent and 26% weaned completely. Consumption at hospital discharge predicted weaning in opioid-naïve patients. Pain catastrophizing, neuropathy, and recreational drug use predicted weaning in opioid-experienced patients.

CONCLUSIONS

The TPS enabled almost half of opioid-naïve patients and one in four opioid-experienced patients to wean. The TPS successfully targets perioperative opioid use in complex pain patients.

摘要

背景

围手术期是解决阿片类药物使用问题的关键时期,尤其是对于有慢性疼痛病史和术前使用阿片类药物的患者。多伦多综合医院过渡性疼痛服务(TPS)旨在解决术后疼痛和阿片类药物使用问题。

目的

提供多伦多综合医院TPS的项目评估结果,重点关注阿片类药物初用者和有阿片类药物使用经验的手术患者的阿片类药物减量率和疼痛管理情况。

方法

251名高危TPS患者在术前被分为阿片类药物初用者或有阿片类药物使用经验者。结果包括疼痛、阿片类药物消耗量、减量率以及心理社会/医学合并症。

结果

术后6个月,疼痛和功能得到显著改善。阿片类药物初用者和有阿片类药物使用经验者的消耗量分别减少了69%和44%。分别有46%和26%的患者完全停用阿片类药物。出院时的消耗量可预测阿片类药物初用者的停药情况。疼痛灾难化、神经病变和娱乐性药物使用可预测有阿片类药物使用经验者的停药情况。

结论

TPS使近一半的阿片类药物初用者和四分之一有阿片类药物使用经验的患者停用了阿片类药物。TPS成功地针对了复杂疼痛患者围手术期的阿片类药物使用情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d9/8730554/b2c3e8f0afa3/UCJP_A_1501669_F0001_OC.jpg

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