自组装DNA-四羟甲基硫酸磷水凝胶作为用于伤口愈合的局部抗菌剂
Self-assembled DNA-THPS hydrogel as a topical antibacterial agent for wound healing.
作者信息
Jiang Xingxing, Li Man, Guo Xiaoxi, Yang Minghui, Rasooly Avraham
机构信息
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P. R. China.
College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, P. R. China.
出版信息
ACS Appl Bio Mater. 2019 Mar 18;2(3):1262-1269. doi: 10.1021/acsabm.8b00818. Epub 2019 Feb 21.
Abstract
We report a novel and potential wound dressing hydrogel based on DNA and a green industrial microbiocide tetrakis (hydroxymethyl) phosphonium sulfate (THPS) via one-pot self-assembly. Intermolecular electrostatic interaction and hydrogen bonding between DNA and THPS together drive the formation of the adhesive DNT (DNA+THPS) hydrogel, featuring with self-healing, shear-thinning and injectability. This wound dressing hydrogel possesses broad-spectrum antibacterial ability with low cytotoxicity to L929 cells. Furthermore, the wound dressing can reduce the risk of wound infection by releasing THPS to suppress bacterial spread and accelerate wound healing. The low cost and simple preparation may make the hydrogel attractive in biomedical applications and could be a good reference to others.
摘要
我们报道了一种基于DNA和绿色工业杀菌剂四羟甲基硫酸磷（THPS）通过一锅法自组装制备的新型潜在伤口敷料水凝胶。DNA与THPS之间的分子间静电相互作用和氢键共同驱动了具有自愈合、剪切变稀和可注射性的粘性DNT（DNA+THPS）水凝胶的形成。这种伤口敷料水凝胶具有广谱抗菌能力，对L929细胞的细胞毒性较低。此外，该伤口敷料可通过释放THPS抑制细菌传播并加速伤口愈合，从而降低伤口感染风险。其低成本和简单的制备方法可能使该水凝胶在生物医学应用中具有吸引力，并可为其他水凝胶提供良好参考。
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