Vaccination and Quarantine Effect on COVID-19 Transmission Dynamics Incorporating Chinese-Spring-Festival Travel Rush: Modeling and Simulations.

The COVID-19 pandemic has adversely affected the entire world. The effective implementation of vaccination strategy is critical to prevent the resurgence of the pandemic, especially during large-scale population migration. We establish a multiple patch coupled model based on the transportation network among the 31 provinces in China, under the combined strategies of vaccination and quarantine during large-scale population migration. Based on the model, we derive a critical quarantine rate to control the pandemic transmission and a vaccination rate to achieve herd immunity. Furthermore, we evaluate the influence of passenger flow on the effective reproduction number during the Chinese-Spring-Festival travel rush. Meanwhile, the spread of the COVID-19 pandemic is investigated for different control strategies, viz. global control and local control. The impact of vaccine-related parameters, such as the number, the effectiveness and the immunity period of vaccine, are explored. It is believed that the articulated models as well as the presented simulation results could be beneficial to design of feasible strategies for preventing COVID-19 transmission during the Chinese-Spring-Festival travel rush or the other future events involving large-scale population migration.