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外泌体相关肿瘤标志物及其检测方法的研究进展

Progress in exosome associated tumor markers and their detection methods.

作者信息

Shen Mengjiao, Di Kaili, He Hongzhang, Xia Yanyan, Xie Hui, Huang Rongrong, Liu Chang, Yang Mo, Zheng Siyang, He Nongyue, Li Zhiyang

机构信息

Department of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Shanghai Health Development Research Center, Shanghai, China.

出版信息

Mol Biomed. 2020 Aug 14;1(1):3. doi: 10.1186/s43556-020-00002-3.

DOI:10.1186/s43556-020-00002-3
PMID:35006428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8603992/
Abstract

Exosomes are secreted by cells and are widely present in body fluids. Exosomes contain various molecular constituents of their cells of origin such as proteins, mRNA, miRNAs, DNA, lipid and glycans which are very similar as the content in tumor cells. These contents play an important role in various stages of tumor development, and make the tumor-derived exosome as a hot and emerging biomarker for various cancers diagnosis and management in non-invasive manner. The present problems of exosome isolation and detection hinder the application of exosomes. With the development of exosome isolation and detection technology, the contents of exosomes can be exploited for early cancer diagnosis. This review summarizes the recent progress on exosome-associated tumor biomarkers and some new technologies for exosome isolation and detection. Furthermore, we have also discussed the future development direction in exosome analysis methods.

摘要

外泌体由细胞分泌，广泛存在于体液中。外泌体包含其来源细胞的各种分子成分，如蛋白质、信使核糖核酸（mRNA）、微小核糖核酸（miRNA）、DNA、脂质和聚糖，这些成分与肿瘤细胞中的含量非常相似。这些成分在肿瘤发展的各个阶段发挥着重要作用，使肿瘤来源的外泌体成为一种热门且新兴的生物标志物，可用于以非侵入性方式对各种癌症进行诊断和管理。外泌体分离和检测目前存在的问题阻碍了其应用。随着外泌体分离和检测技术的发展，外泌体的成分可用于早期癌症诊断。本文综述了外泌体相关肿瘤生物标志物的最新进展以及一些外泌体分离和检测的新技术。此外，我们还讨论了外泌体分析方法的未来发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/73f131656802/43556_2020_2_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/1beb8251a0ef/43556_2020_2_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/fb7e04ddde0a/43556_2020_2_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/6ddfad0b4c53/43556_2020_2_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/eab1ce242bdc/43556_2020_2_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/44ebd295c6cf/43556_2020_2_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/745cb53bdac1/43556_2020_2_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/46dacb668436/43556_2020_2_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/1c81724459da/43556_2020_2_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/f600077b4750/43556_2020_2_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/73f131656802/43556_2020_2_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/1beb8251a0ef/43556_2020_2_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/fb7e04ddde0a/43556_2020_2_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/6ddfad0b4c53/43556_2020_2_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/eab1ce242bdc/43556_2020_2_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/44ebd295c6cf/43556_2020_2_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/745cb53bdac1/43556_2020_2_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/46dacb668436/43556_2020_2_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/1c81724459da/43556_2020_2_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/f600077b4750/43556_2020_2_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b8b/8603992/73f131656802/43556_2020_2_Fig10_HTML.jpg

相似文献

[1]
Progress in exosome associated tumor markers and their detection methods.

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[2]
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[4]
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[8]
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[10]
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[5]
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[6]
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[7]
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[8]
Proteomic analysis of small extracellular vesicles unique to cervical cancer.

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[9]
Liquid biopsy for early detection and therapeutic monitoring of hepatocellular carcinoma.

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本文引用的文献

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Science. 2020-2-7

[2]
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Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1.

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