Polymer and Biomaterials Chemistry Laboratories, University of Bradford, Bradford, West Yorkshire BD 7 1DP, U.K.
Smith and Nephew Wound Management, Hull HU3 2AH, U.K.
ACS Appl Bio Mater. 2021 May 17;4(5):4319-4327. doi: 10.1021/acsabm.1c00116. Epub 2021 Apr 27.
Highly branched poly(-isopropylacrylamide) (HB-PNIPAM), functionalized with vancomycin at the chain ends, acted as a bacterial adhesive and was incorporated into polyurethane foams to form semi-interpenetrating networks. PNIPAM was labeled with a solvatochromic dye, Nile red. It was found that the thermal response of the polymer was dependent on the architecture, and temperature-dependent color changes were observed within the foam. The foams had open pore structures, and the presence of HB-PNIPAM substantially reduced the shrinkage of the foam as the temperature was increased up to 20 °C. The foams were selectively adhesive for (Gram-positive bacteria) compared to (Gram-negative bacteria), and the presence of was indicated by increased fluorescence intensity (590-800 nm).
高度支化的聚（异丙基丙烯酰胺）（HB-PNIPAM），在链端用万古霉素官能化，作为细菌的黏附剂，并被掺入聚氨酯泡沫中形成半互穿网络。PNIPAM 用溶剂致变色染料尼罗红标记。结果发现，聚合物的热响应取决于结构，并在泡沫内观察到温度依赖性的颜色变化。泡沫具有开孔结构，随着温度升高至 20°C，HB-PNIPAM 的存在大大减少了泡沫的收缩。与 （革兰氏阴性菌）相比，泡沫对 （革兰氏阳性菌）具有选择性黏附性，并且通过荧光强度的增加（590-800nm）表明 的存在。
