Kekow J, Kern P, Schmitz H, Gross W L
Department of Internal Medicine, Christian Albrecht University, Kiel, Federal Republic of Germany.
Cancer Detect Prev Suppl. 1987;1:543-8.
In addition to the well known T-cell dysfunctions in AIDS, hypergammaglobulinaemia and autoimmune phenomena indicate an involvement of the B cell as well. Reports of HTLV-III/LAV-infected B cells suggest T-cell-independent B-cell abnormalities. To look for early B-cell dysfunctions, we examined a high-risk group of AIDS consisting of six homosexuals with PGL and HTLV-III/LAV antibodies, comparing these data to those of patients with AIDS/ARC and a normal control. In vitro studies included the B-cell proliferation response (3H-thymidine uptake) to Staphylococcus aureus Cowan I and the differentiation response (Ig secretion into culture supernatants) to T-cell-dependent/-independent polyclonal B-cell activators (PBAs). Profound alterations were found in both the proliferation and the differentiation responses. The weak response even to T-cell-independent PBAs indicates a B-cell dysfunction that is not due only to a T-cell defect in patients with PGL, similar to that observed in AIDS.
除了艾滋病中众所周知的T细胞功能障碍外，高丙种球蛋白血症和自身免疫现象表明B细胞也受到了影响。关于感染人嗜T淋巴细胞病毒III型/淋巴腺病相关病毒（HTLV-III/LAV）的B细胞的报道提示了不依赖T细胞的B细胞异常。为了寻找早期B细胞功能障碍，我们检查了一组高危艾滋病患者，其中包括六名患有持续性全身性淋巴结病（PGL）且有HTLV-III/LAV抗体的同性恋者，并将这些数据与艾滋病/艾滋病相关综合征（ARC）患者及正常对照的数据进行比较。体外研究包括B细胞对金黄色葡萄球菌Cowan I的增殖反应（3H-胸腺嘧啶核苷摄取）以及对依赖T细胞/不依赖T细胞的多克隆B细胞激活剂（PBA）的分化反应（Ig分泌到培养上清液中）。在增殖反应和分化反应中均发现了显著改变。即使对不依赖T细胞的PBA反应微弱，也表明B细胞功能障碍，这并非仅由PGL患者的T细胞缺陷所致，类似于在艾滋病中观察到的情况。
