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CRISPR/Cas9 genome-edited universal CAR T cells in patients with relapsed/refractory lymphoma.

作者信息

Guo Yelei, Tong Chuan, Su Liping, Zhang Wenying, Jia Hejin, Liu Yang, Yang Qingming, Wu Zhiqiang, Wang Yao, Han Weidong

机构信息

Department of Bio-therapeutics, First Medical Centre, Chinese PLA General Hospital, Beijing, China.

Department of Hematology, Shanxi Cancer Hospital, Shanxi, China; and.

出版信息

Blood Adv. 2022 Apr 26;6(8):2695-2699. doi: 10.1182/bloodadvances.2021006232.

DOI:10.1182/bloodadvances.2021006232
PMID:35008103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9043938/
Abstract
摘要

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Mutant B2M-HLA-E and B2M-HLA-G fusion proteins protects universal chimeric antigen receptor-modified T cells from allogeneic NK cell-mediated lysis.突变体 B2M-HLA-E 和 B2M-HLA-G 融合蛋白可保护通用嵌合抗原受体修饰的 T 细胞免受同种异体 NK 细胞介导的裂解。
Eur J Immunol. 2021 Oct;51(10):2513-2521. doi: 10.1002/eji.202049107. Epub 2021 Aug 19.
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Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies.基因编辑的、供体来源的同种异体抗 CD19 嵌合抗原受体 T 细胞治疗儿童和成人 B 细胞急性淋巴细胞白血病:两项 1 期研究结果。
Lancet. 2020 Dec 12;396(10266):1885-1894. doi: 10.1016/S0140-6736(20)32334-5.
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提高嵌合抗原受体T细胞疗法治疗淋巴瘤免疫治疗效果的策略进展
Cancer Biol Med. 2025 Apr 15;22(4):301-21. doi: 10.20892/j.issn.2095-3941.2024.0538.
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The role of B2M in cancer immunotherapy resistance: function, resistance mechanism, and reversal strategies.B2M在癌症免疫治疗耐药中的作用:功能、耐药机制及逆转策略
Front Immunol. 2025 Mar 21;16:1512509. doi: 10.3389/fimmu.2025.1512509. eCollection 2025.
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Clinical development of allogeneic chimeric antigen receptor αβ-T cells.同种异体嵌合抗原受体αβ-T细胞的临床开发
Mol Ther. 2025 Jun 4;33(6):2426-2440. doi: 10.1016/j.ymthe.2025.03.040. Epub 2025 Mar 27.
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HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells.表达HLA-E的多能干细胞可逃避自然杀伤细胞的同种异体反应和裂解。
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