Chen Chaoran, Ding Yueming, Liu Huiyang, Sun Mengyao, Wang Honggang, Wu Dongdong
Institute of Nursing and Health, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng 475004, China.
Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Int J Mol Sci. 2022 Jan 4;23(1):519. doi: 10.3390/ijms23010519.
Flubendazole, belonging to benzimidazole, is a broad-spectrum insect repellent and has been repurposed as a promising anticancer drug. In recent years, many studies have shown that flubendazole plays an anti-tumor role in different types of cancers, including breast cancer, melanoma, prostate cancer, colorectal cancer, and lung cancer. Although the anti-tumor mechanism of flubendazole has been studied, it has not been fully understood. In this review, we summarized the recent studies regarding the anti-tumor effects of flubendazole in different types of cancers and analyzed the related mechanisms, in order to provide the theoretical reference for further studies in the future.
氟苯达唑属于苯并咪唑类，是一种广谱驱虫剂，已被重新用作一种有前景的抗癌药物。近年来，许多研究表明氟苯达唑在不同类型的癌症中发挥抗肿瘤作用，包括乳腺癌、黑色素瘤、前列腺癌、结直肠癌和肺癌。尽管已经对氟苯达唑的抗肿瘤机制进行了研究，但尚未完全了解。在本综述中，我们总结了关于氟苯达唑在不同类型癌症中的抗肿瘤作用的最新研究，并分析了相关机制，以便为未来的进一步研究提供理论参考。
