College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
National Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006, China.
Int J Mol Sci. 2022 Jan 4;23(1):530. doi: 10.3390/ijms23010530.
MicroRNA408 () is an ancient and highly conserved miRNA, which is involved in the regulation of plant growth, development and stress response. However, previous research results on the evolution and functional roles of and its targets are relatively scattered, and there is a lack of a systematic comparison and comprehensive summary of the detailed evolutionary pathways and regulatory mechanisms of and its targets in plants. Here, we analyzed the evolutionary pathway of in plants, and summarized the functions of and its targets in regulating plant growth and development and plant responses to various abiotic and biotic stresses. The evolutionary analysis shows that is an ancient and highly conserved microRNA, which is widely distributed in different plants. regulates the growth and development of different plants by down-regulating its targets, encoding blue copper (Cu) proteins, and by transporting Cu to plastocyanin (PC), which affects photosynthesis and ultimately promotes grain yield. In addition, improves tolerance to stress by down-regulating target genes and enhancing cellular antioxidants, thereby increasing the antioxidant capacity of plants. This review expands and promotes an in-depth understanding of the evolutionary and regulatory roles of and its targets in plants.
miRNA408（miRNA408）是一种古老且高度保守的 miRNA，参与植物生长、发育和应激反应的调控。然而，以前关于 miRNA408 和其靶基因的进化和功能作用的研究结果相对分散，缺乏对 miRNA408 和其靶基因在植物中详细进化途径和调控机制的系统比较和综合总结。在这里，我们分析了 miRNA408 在植物中的进化途径，并总结了 miRNA408 和其靶基因在调节植物生长发育和植物对各种非生物和生物胁迫的反应中的功能。进化分析表明，miRNA408 是一种古老且高度保守的 miRNA，广泛分布于不同的植物中。miRNA408 通过下调其靶基因编码的蓝色铜（Cu）蛋白，并将 Cu 运送到质体蓝素（PC），影响光合作用，最终促进谷物产量，从而调节不同植物的生长发育。此外，miRNA408 通过下调靶基因和增强细胞抗氧化剂来提高对胁迫的耐受性，从而提高植物的抗氧化能力。本综述扩展并促进了对 miRNA408 和其靶基因在植物中的进化和调控作用的深入理解。
