Krymskaya L G, Kozlov V A
Institute of Clinical Immunology, Siberian Branch of the Academy of Medical Sciences, Novosibirsk, U.S.S.R.
Immunol Lett. 1987 Aug;15(4):307-9. doi: 10.1016/0165-2478(87)90133-7.
The effect of interleukin 1, the product of macrophage secretion, on mouse (CBA x C57Bl)F1 adrenal gland function has been studied in this paper. The maximal response of adrenal glands to intravenous interleukin 1 injection was observed after 2 h. The stimulation of adrenal gland hormonal function was dose-dependent as shown by i.v. injection of different dilutions of macrophage culture supernatants containing interleukin 1. The effect of interleukin 1 on functional adrenal gland activity was shown to be mediated by prostaglandin synthesis in an experiment in which prostaglandin synthesis was inhibited by indomethacin (0.25 mg/mouse). The hormonal adrenal gland response to interleukin 1 injection may well be part of a mechanism of negative feedback between interleukin 1 production and glucocorticoid level in blood plasma.
本文研究了巨噬细胞分泌产物白细胞介素-1对小鼠（CBA×C57Bl）F1肾上腺功能的影响。静脉注射白细胞介素-1后2小时观察到肾上腺的最大反应。静脉注射含有白细胞介素-1的巨噬细胞培养上清液的不同稀释液表明，肾上腺激素功能的刺激呈剂量依赖性。在吲哚美辛（0.25mg/小鼠）抑制前列腺素合成的实验中，白细胞介素-1对肾上腺功能活性的影响被证明是由前列腺素合成介导的。肾上腺对白细胞介素-1注射的激素反应很可能是白细胞介素-1产生与血浆糖皮质激素水平之间负反馈机制的一部分。
