Roh M S, Drazenovich K A, Barbose J J, Dinarello C A, Cobb C F
Surgery. 1987 Aug;102(2):140-6.
The impact of human recombinant beta-interleukin-1 (IL-1) on adrenocortical stimulation was investigated. This study asked three questions: Does IL-1 increase the corticosterone levels of rat serum? Is there a direct effect on the adrenal cortex? What is the mechanism of this effect? The intraperitoneal injection of IL-1 (70 micrograms) in anesthetized male Fisher rats resulted in elevated corticosterone levels at 30 minutes and reached a maximum at 180 minutes (94 +/- 12 versus 34 +/- 4 micrograms/dl, p less than 0.01). Next, the adrenal glands from separate animals were perfused in situ. Corticosterone secretion was significantly increased (p less than 0.01) 90 minutes after a single arterial bolus of 35 micrograms of IL-1. The response to IL-1 was dose dependent, beginning at 3.5 micrograms and reaching a maximum at 35 micrograms. The addition of indomethacin (3 mumol/L) completely abolished the stimulatory effect of IL-1. This study demonstrates that IL-1 increases rat serum corticosterone levels, IL-1 directly stimulates the adrenal cortex, and the stimulation may be mediated through prostaglandin synthesis. This is the first evidence that IL-1 has a direct stimulatory effect on the adrenal cortex.
研究了重组人β-白细胞介素-1（IL-1）对肾上腺皮质刺激的影响。本研究提出了三个问题：IL-1是否会增加大鼠血清皮质酮水平？对肾上腺皮质是否有直接作用？这种作用的机制是什么？对麻醉的雄性Fisher大鼠腹腔注射IL-1（70微克），30分钟时皮质酮水平升高，180分钟时达到最高值（94±12对34±4微克/分升，p<0.01）。接下来，对单独动物的肾上腺进行原位灌注。单次动脉推注35微克IL-1后90分钟，皮质酮分泌显著增加（p<0.01）。对IL-1的反应呈剂量依赖性，从3.5微克开始，35微克时达到最大值。加入吲哚美辛（3微摩尔/升）可完全消除IL-1的刺激作用。本研究表明，IL-1可增加大鼠血清皮质酮水平，IL-1直接刺激肾上腺皮质，且该刺激可能通过前列腺素合成介导。这是IL-1对肾上腺皮质有直接刺激作用的首个证据。
