用于合成发光染料和溶胶-凝胶杂化材料的高效一锅法的开发。

Zdończyk Maria, Potaniec Bartłomiej, Skoreński Marcin, Cybińska Joanna

Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14 Street, 50-383 Wrocław, Poland.

Advanced Materials Synthesis Group, Łukasiewicz Research Network-PORT Polish Center for Technology, Stabłowicka 147 Street, 54-066 Wrocław, Poland.

Materials (Basel). 2021 Dec 28;15(1):203. doi: 10.3390/ma15010203.

This paper presents a comparison of the simultaneous preparation of di--alkylated and ether-ester derivatives of fluorescein using different methods (conventional or microwave heating). Shortening of the reaction time and increased efficiency were observed when using a microwave reactor. Moreover, described here for the first time is the application of a fast, simple, and eco-friendly ball-assisted method to exclusively obtain ether-ester derivatives. We also demonstrate that fluorescein can be effectively functionalized by -alkylation carried out under microwave or ball-milling conditions, saving time and energy and affording the desired products with good yields and minimal byproduct formation. All the synthesized products as well as pH-dependent (prototropic) forms trapped in the SiO matrix were examined using UV-Vis and fluorescence spectroscopy.

本文比较了使用不同方法（传统加热或微波加热）同时制备荧光素的二烷基化衍生物和醚酯衍生物的情况。使用微波反应器时，反应时间缩短且效率提高。此外，本文首次描述了一种快速、简单且环保的球辅助方法，该方法可专门用于获得醚酯衍生物。我们还证明，在微波或球磨条件下进行的烷基化反应能够有效地使荧光素官能化，既节省时间和能源，又能以良好的产率获得所需产物，且副产物生成量最少。使用紫外可见光谱和荧光光谱对所有合成产物以及捕获在SiO基质中的pH依赖性（质子转移）形式进行了检测。