Dulińska-Litewka Joanna, Dykas Kacper, Felkle Dominik, Karnas Karolina, Khachatryan Gohar, Karewicz Anna
Chair of Medical Biochemistry, Jagiellonian University Medical College, Mikołaja Kopernika Street 7C, 31-034 Krakow, Poland.
Department of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Cracow, Poland.
Materials (Basel). 2021 Dec 29;15(1):234. doi: 10.3390/ma15010234.
For the last years scientific community has witnessed a rapid development of novel types of biomaterials, which properties made them applicable in numerous fields of medicine. Although nanosilver, well-known for its antimicrobial, anti-angiogenic, anti-inflammatory and anticancer activities, as well as hyaluronic acid, a natural polysaccharide playing a vital role in the modulation of tissue repair, signal transduction, angiogenesis, cell motility and cancer metastasis, are both thoroughly described in the literature, their complexes are still a novel topic. In this review we introduce the most recent research about the synthesis, properties, and potential applications of HA-nanosilver composites. We also make an attempt to explain the variety of mechanisms involved in their action. Finally, we present biocompatible and biodegradable complexes with bactericidal activity and low cytotoxicity, which properties suggest their suitability for the prophylaxis and therapy of chronic wounds, as well as analgetic therapies, anticancer strategies and the detection of chemical substances and malignant cells. Cited studies reveal that the usage of hyaluronic acid-silver nanocomposites appears to be efficient and safe in clinical practice.
在过去几年中，科学界见证了新型生物材料的快速发展，它们的特性使其适用于众多医学领域。尽管纳米银以其抗菌、抗血管生成、抗炎和抗癌活性而闻名，以及透明质酸，一种在组织修复、信号转导、血管生成、细胞运动和癌症转移调节中起重要作用的天然多糖，在文献中都有详尽描述，但它们的复合物仍然是一个新课题。在本综述中，我们介绍了关于HA-纳米银复合材料的合成、性质和潜在应用的最新研究。我们还试图解释其作用涉及的多种机制。最后，我们展示了具有杀菌活性和低细胞毒性的生物相容性和可生物降解的复合物，这些特性表明它们适用于慢性伤口的预防和治疗，以及镇痛疗法、抗癌策略和化学物质及恶性细胞的检测。引用的研究表明，透明质酸-银纳米复合材料在临床实践中的使用似乎是有效且安全的。
