• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

具有银纳米颗粒的非细胞毒性、温度响应性且抗菌的基于聚（2-恶唑啉基乙基甲基丙烯酸酯）的纳米复合涂层

Non-cytotoxic, temperature-responsive and antibacterial POEGMA based nanocomposite coatings with silver nanoparticles.

作者信息

Nastyshyn Svyatoslav, Raczkowska Joanna, Stetsyshyn Yurij, Orzechowska Barbara, Bernasik Andrzej, Shymborska Yana, Brzychczy-Włoch Monika, Gosiewski Tomasz, Lishchynskyi Ostap, Ohar Halyna, Ochońska Dorota, Awsiuk Kamil, Budkowski Andrzej

机构信息

Smoluchowski Institute of Physics, Jagiellonian University Łojasiewicza 11 30-348 Kraków Poland

Lviv Polytechnic National University St. George's Square 2 79013 Lviv Ukraine

出版信息

RSC Adv. 2020 Mar 10;10(17):10155-10166. doi: 10.1039/c9ra10874b. eCollection 2020 Mar 6.

DOI:10.1039/c9ra10874b
PMID:35498562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9050227/
Abstract

Non-cytotoxic, temperature-responsive and antibacterial poly(di(ethylene glycol)methyl ether methacrylate) - POEGMA188 based nanocomposite coatings attached to a glass surface were successfully prepared using ATRP polymerization. The thickness, morphology and wettability of the resulting coatings were analyzed using ellipsometry, AFM and contact angle measurements, respectively. The strong impact of the thicknesses of the POEGMA188 grafted brush coatings and content of AgNPs on the morphology and temperature-induced wettability changes of the nanocomposite was demonstrated. In addition to the strong temperature-dependent antibacterial activity, the proposed nanocomposite coatings have no significant cytotoxic effect towards normal cells. Moreover, the slight anti-cancer effect of AgNPs may be suggested.

摘要

采用原子转移自由基聚合（ATRP）成功制备了附着在玻璃表面的非细胞毒性、温度响应性和抗菌的聚（甲基丙烯酸二（乙二醇）甲醚）-POEGMA188基纳米复合涂层。分别使用椭偏仪、原子力显微镜（AFM）和接触角测量法对所得涂层的厚度、形态和润湿性进行了分析。结果表明，接枝有POEGMA188的刷状涂层的厚度以及纳米银颗粒（AgNPs）的含量对纳米复合材料的形态和温度诱导的润湿性变化有强烈影响。除了具有强烈的温度依赖性抗菌活性外，所提出的纳米复合涂层对正常细胞没有显著的细胞毒性作用。此外，还可能暗示了AgNPs具有轻微的抗癌作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/8387bdc73f53/c9ra10874b-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/d78bd5b3d0c4/c9ra10874b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/1fbc5d00ab4a/c9ra10874b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/237df4f98e60/c9ra10874b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/c0add1ad3705/c9ra10874b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/8ca25d6da9bb/c9ra10874b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/84973c24a847/c9ra10874b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/46f6144be757/c9ra10874b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/8387bdc73f53/c9ra10874b-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/d78bd5b3d0c4/c9ra10874b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/1fbc5d00ab4a/c9ra10874b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/237df4f98e60/c9ra10874b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/c0add1ad3705/c9ra10874b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/8ca25d6da9bb/c9ra10874b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/84973c24a847/c9ra10874b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/46f6144be757/c9ra10874b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc65/9050227/8387bdc73f53/c9ra10874b-f7.jpg

相似文献

1
Non-cytotoxic, temperature-responsive and antibacterial POEGMA based nanocomposite coatings with silver nanoparticles.具有银纳米颗粒的非细胞毒性、温度响应性且抗菌的基于聚（2-恶唑啉基乙基甲基丙烯酸酯）的纳米复合涂层
RSC Adv. 2020 Mar 10;10(17):10155-10166. doi: 10.1039/c9ra10874b. eCollection 2020 Mar 6.
2
"Command" surfaces with thermo-switchable antibacterial activity.具有热开关型抗菌活性的“命令”表面。
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109806. doi: 10.1016/j.msec.2019.109806. Epub 2019 May 27.
3
Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCO Nanoparticles on Different Cell Lines.嵌入碳酸钙纳米颗粒的减污温度响应性聚乙二醇甲基丙烯酸酯涂层的制备及其对不同细胞系的影响
Materials (Basel). 2021 Mar 15;14(6):1417. doi: 10.3390/ma14061417.
4
Temperature- and pH-Responsive Schizophrenic Copolymer Brush Coatings with Enhanced Temperature Response in Pure Water.温度和 pH 值响应型精神分裂共聚刷涂层在纯水中具有增强的温度响应。
ACS Appl Mater Interfaces. 2023 Feb 15;15(6):8676-8690. doi: 10.1021/acsami.2c20395. Epub 2023 Feb 3.
5
Preparation and antibacterial activity of silver-loaded poly(oligo(ethylene glycol) methacrylate) brush.载银聚（氧乙烯基甲基丙烯酸酯）刷的制备及抗菌活性。
J Biomater Sci Polym Ed. 2019 May-Jun;30(9):756-768. doi: 10.1080/09205063.2019.1603066. Epub 2019 Apr 19.
6
Glass transition in temperature-responsive poly(butyl methacrylate) grafted polymer brushes. Impact of thickness and temperature on wetting, morphology, and cell growth.温度响应性聚（甲基丙烯酸丁酯）接枝聚合物刷中的玻璃化转变。厚度和温度对润湿性、形态及细胞生长的影响。
J Mater Chem B. 2018 Mar 21;6(11):1613-1621. doi: 10.1039/c8tb00088c. Epub 2018 Feb 28.
7
Temperature and pH dual-responsive POEGMA-based coatings for protein adsorption.温敏和 pH 响应性 POEGMA 基涂层用于蛋白质吸附。
J Colloid Interface Sci. 2013 Dec 1;411:247-56. doi: 10.1016/j.jcis.2013.08.007. Epub 2013 Aug 23.
8
Temperature-Controlled Three-Stage Switching of Wetting, Morphology, and Protein Adsorption.温度控制的三阶段润湿、形态和蛋白质吸附切换。
ACS Appl Mater Interfaces. 2017 Apr 5;9(13):12035-12045. doi: 10.1021/acsami.7b00136. Epub 2017 Mar 22.
9
Temperature-Controlled Orientation of Proteins on Temperature-Responsive Grafted Polymer Brushes: Poly(butyl methacrylate) vs Poly(butyl acrylate): Morphology, Wetting, and Protein Adsorption.温度响应性接枝聚合物刷上蛋白质的温度控制取向：聚（甲基丙烯酸丁酯）与聚（丙烯酸丁酯）：形态、润湿性和蛋白质吸附。
Biomacromolecules. 2019 Jun 10;20(6):2185-2197. doi: 10.1021/acs.biomac.9b00030. Epub 2019 May 7.
10
Cellulose nanocrystal-poly(oligo(ethylene glycol) methacrylate) brushes with tunable LCSTs.具有可调 LCST 的纤维素纳米晶-聚（聚乙二醇甲基丙烯酸酯）刷。
Carbohydr Polym. 2016 Jun 25;144:215-22. doi: 10.1016/j.carbpol.2016.02.044. Epub 2016 Feb 18.

引用本文的文献

1
Development of Smart Surfaces for Medicine and Biotechnology: Advances in Glass Functionalization through RDRP Techniques.用于医学和生物技术的智能表面的开发：通过自由基可控聚合技术实现玻璃功能化的进展。
ACS Biomater Sci Eng. 2025 Aug 11;11(8):4694-4713. doi: 10.1021/acsbiomaterials.5c00908. Epub 2025 Jul 31.
2
Emerging trends and future challenges of advanced 2D nanomaterials for combating bacterial resistance.用于抗细菌耐药性的先进二维纳米材料的新兴趋势与未来挑战
Bioact Mater. 2024 May 7;38:225-257. doi: 10.1016/j.bioactmat.2024.04.033. eCollection 2024 Aug.
3
Surface Modification of PP and PBT Nonwoven Membranes for Enhanced Efficiency in Photocatalytic MB Dye Removal and Antibacterial Activity.

本文引用的文献

1
"Command" surfaces with thermo-switchable antibacterial activity.具有热开关型抗菌活性的“命令”表面。
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109806. doi: 10.1016/j.msec.2019.109806. Epub 2019 May 27.
2
Cytotoxic Potential and Molecular Pathway Analysis of Silver Nanoparticles in Human Colon Cancer Cells HCT116.银纳米粒子对人结肠癌细胞 HCT116 的细胞毒性及其分子途径分析。
Int J Mol Sci. 2018 Aug 2;19(8):2269. doi: 10.3390/ijms19082269.
3
A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives.
用于提高光催化去除亚甲基蓝染料效率和抗菌活性的聚丙烯和聚对苯二甲酸丁二醇酯非织造膜的表面改性
Polymers (Basel). 2023 Aug 11;15(16):3378. doi: 10.3390/polym15163378.
4
An Overview of Stimuli-Responsive Intelligent Antibacterial Nanomaterials.刺激响应型智能抗菌纳米材料概述
Pharmaceutics. 2023 Aug 9;15(8):2113. doi: 10.3390/pharmaceutics15082113.
5
Inhibition of Adherence and Biofilm Formation of by Immobilized ZnO Nanoparticles on Silicone Urinary Catheter Grafted by Gamma Irradiation.γ射线辐照接枝的硅胶导尿管上固定化ZnO纳米颗粒对[具体细菌名称未给出]黏附及生物膜形成的抑制作用
Microorganisms. 2023 Mar 31;11(4):913. doi: 10.3390/microorganisms11040913.
6
Temperature- and pH-Responsive Schizophrenic Copolymer Brush Coatings with Enhanced Temperature Response in Pure Water.温度和 pH 值响应型精神分裂共聚刷涂层在纯水中具有增强的温度响应。
ACS Appl Mater Interfaces. 2023 Feb 15;15(6):8676-8690. doi: 10.1021/acsami.2c20395. Epub 2023 Feb 3.
7
Temperature-Responsive Polymer Brush Coatings for Advanced Biomedical Applications.用于先进生物医学应用的温度响应性聚合物刷涂层
Polymers (Basel). 2022 Oct 10;14(19):4245. doi: 10.3390/polym14194245.
8
Recent Advances in the Control of Clinically Important Biofilms.临床重要生物膜控制的最新进展。
Int J Mol Sci. 2022 Aug 23;23(17):9526. doi: 10.3390/ijms23179526.
9
Passive antifouling and active self-disinfecting antiviral surfaces.被动防污和主动自消毒抗病毒表面。
Chem Eng J. 2022 Oct 15;446:137048. doi: 10.1016/j.cej.2022.137048. Epub 2022 May 18.
10
Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections.用于治疗与设备相关感染的多刺激响应多层涂层
J Funct Biomater. 2022 Feb 28;13(1):24. doi: 10.3390/jfb13010024.
银纳米颗粒诱导细胞毒性的系统综述：物理化学性质与展望
J Adv Res. 2017 Nov 2;9:1-16. doi: 10.1016/j.jare.2017.10.008. eCollection 2018 Jan.
4
Temperature-Responsive Hierarchical Polymer Brushes Switching from Bactericidal to Cell Repellency.温度响应性分级聚合物刷从杀菌到细胞排斥的转变。
ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40930-40939. doi: 10.1021/acsami.7b09968. Epub 2017 Nov 13.
5
Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy.银纳米颗粒在F9畸胎癌干细胞中的双重功能，F9畸胎癌干细胞是评估细胞毒性和分化介导的癌症治疗的合适模型。
Int J Nanomedicine. 2017 Oct 12;12:7529-7549. doi: 10.2147/IJN.S145147. eCollection 2017.
6
Substrate-Independent Ag-Nanoparticle-Loaded Hydrogel Coating with Regenerable Bactericidal and Thermoresponsive Antibacterial Properties.具有可再生杀菌和温敏抗菌性能的基底非依赖型 Ag 纳米粒子负载水凝胶涂层。
ACS Appl Mater Interfaces. 2017 Dec 27;9(51):44782-44791. doi: 10.1021/acsami.7b13238. Epub 2017 Dec 14.
7
Smart Antibacterial Surfaces with Switchable Bacteria-Killing and Bacteria-Releasing Capabilities.具有可切换杀菌和释菌功能的智能抗菌表面。
ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37511-37523. doi: 10.1021/acsami.7b13565. Epub 2017 Oct 18.
8
The effects of silver nanoparticles on mouse embryonic stem cell self-renewal and proliferation.银纳米颗粒对小鼠胚胎干细胞自我更新和增殖的影响。
Toxicol Rep. 2015 May 16;2:758-764. doi: 10.1016/j.toxrep.2015.05.005. eCollection 2015.
9
Anti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell line.白蛋白包覆的银纳米粒子对 MDA-MB-231 人乳腺癌细胞系的抗癌作用。
Sci Rep. 2017 Jul 12;7(1):5178. doi: 10.1038/s41598-017-05461-3.
10
Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering.原子力显微镜：一种用于解决组织工程中支架设计问题的强大工具。
J Funct Biomater. 2017 Feb 13;8(1):7. doi: 10.3390/jfb8010007.