Nastyshyn Svyatoslav, Raczkowska Joanna, Stetsyshyn Yurij, Orzechowska Barbara, Bernasik Andrzej, Shymborska Yana, Brzychczy-Włoch Monika, Gosiewski Tomasz, Lishchynskyi Ostap, Ohar Halyna, Ochońska Dorota, Awsiuk Kamil, Budkowski Andrzej
Smoluchowski Institute of Physics, Jagiellonian University Łojasiewicza 11 30-348 Kraków Poland
Lviv Polytechnic National University St. George's Square 2 79013 Lviv Ukraine
RSC Adv. 2020 Mar 10;10(17):10155-10166. doi: 10.1039/c9ra10874b. eCollection 2020 Mar 6.
Non-cytotoxic, temperature-responsive and antibacterial poly(di(ethylene glycol)methyl ether methacrylate) - POEGMA188 based nanocomposite coatings attached to a glass surface were successfully prepared using ATRP polymerization. The thickness, morphology and wettability of the resulting coatings were analyzed using ellipsometry, AFM and contact angle measurements, respectively. The strong impact of the thicknesses of the POEGMA188 grafted brush coatings and content of AgNPs on the morphology and temperature-induced wettability changes of the nanocomposite was demonstrated. In addition to the strong temperature-dependent antibacterial activity, the proposed nanocomposite coatings have no significant cytotoxic effect towards normal cells. Moreover, the slight anti-cancer effect of AgNPs may be suggested.
采用原子转移自由基聚合（ATRP）成功制备了附着在玻璃表面的非细胞毒性、温度响应性和抗菌的聚（甲基丙烯酸二（乙二醇）甲醚）-POEGMA188基纳米复合涂层。分别使用椭偏仪、原子力显微镜（AFM）和接触角测量法对所得涂层的厚度、形态和润湿性进行了分析。结果表明，接枝有POEGMA188的刷状涂层的厚度以及纳米银颗粒（AgNPs）的含量对纳米复合材料的形态和温度诱导的润湿性变化有强烈影响。除了具有强烈的温度依赖性抗菌活性外，所提出的纳米复合涂层对正常细胞没有显著的细胞毒性作用。此外，还可能暗示了AgNPs具有轻微的抗癌作用。
