Torné-Morató Helena, Donati Paolo, Pompa Pier Paolo
Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia (IIT), via Morego, 30-16163 Genova, Italy.
Department of Chemistry and Industrial Chemistry, University of Genova, via Dodecaneso, 31-16146 Genova, Italy.
Nanomaterials (Basel). 2021 Dec 29;12(1):105. doi: 10.3390/nano12010105.
Nowadays, there is an increasing interest in Point-of-care (POC) devices for the noninvasive glucose assessment. Despite the recent progress in glucose self-monitoring, commercially available devices still use invasive samples such as blood or interstitial fluids, and they are not equipment-free and affordable for the whole population. Here, we report a fully integrated strip test for the semi-quantitative detection of glucose in whole saliva. The colorimetric mechanism consists of an enzyme-mediated reshaping of multibranched gold nanoparticles (MGNPs) into nanospheres with an associated plasmonic shift and consequent blue-to-red color change, clearly detectable in less than 10 min.
如今，人们对用于无创血糖评估的即时检测（POC）设备越来越感兴趣。尽管近年来血糖自我监测取得了进展，但市售设备仍使用血液或间质液等侵入性样本，而且并非所有人都能负担得起且无需设备。在此，我们报告了一种用于全唾液中葡萄糖半定量检测的全集成试纸条测试。比色机制包括酶介导的多分支金纳米颗粒（MGNPs）重塑为纳米球，伴随等离子体位移以及随之而来的从蓝色到红色的颜色变化，在不到10分钟内即可清晰检测到。
