Liu Peiyun, Zhou Wangting, Xu Weiqi, Peng Yujia, Yan Yamei, Lu Lu, Mi Jia, Zeng Xiaoxiong, Cao Youlong
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Institute of Wolfberry Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China.
Foods. 2021 Dec 30;11(1):98. doi: 10.3390/foods11010098.
Anthocyanins have been shown to exert certain antiobesity properties, but the specific relationship between anthocyanin-induced beneficial effects and the gut microbiota remains unclear. Petunidin-3--[rhamnopyranosyl-(trans--coumaroyl)]-5--(β-D-glucopyranoside) (P3G) is the main anthocyanin monomer from the fruit of Murray. Therefore, in this study, we investigated the antiobesity and remodeling effects of P3G on gut microbiota through a high-fat diet (HFD)-induced obesity mouse model and a fecal microbiota transplantation experiment. P3G was found to reduce body weight gain, fat accumulation, and liver steatosis in HFD-induced obese mice. Moreover, supplementation with P3G alleviated the HFD-induced imbalance in gut microbiota composition, and transferring the P3G-regulated gut microbiota to recipient mice provided comparable protection against obesity. This is the first time evidence is provided that P3G has an antiobesity effect by changing the intestinal microbiota. Our present data highlight a link between P3G intervention and enhancement in gut barrier integrity. This may be a promising option for obesity prevention.
花青素已被证明具有一定的抗肥胖特性，但花青素诱导的有益作用与肠道微生物群之间的具体关系仍不清楚。矮牵牛素-3- - [鼠李糖基-(反式-香豆酰)]-5- - (β-D-葡萄糖苷)(P3G)是来自默里氏果实的主要花青素单体。因此，在本研究中，我们通过高脂饮食(HFD)诱导的肥胖小鼠模型和粪便微生物群移植实验，研究了P3G对肠道微生物群的抗肥胖和重塑作用。研究发现，P3G可减轻HFD诱导的肥胖小鼠的体重增加、脂肪堆积和肝脏脂肪变性。此外，补充P3G可缓解HFD诱导的肠道微生物群组成失衡，将P3G调节的肠道微生物群转移到受体小鼠中可提供类似的抗肥胖保护。这是首次有证据表明P3G通过改变肠道微生物群具有抗肥胖作用。我们目前的数据突出了P3G干预与肠道屏障完整性增强之间的联系。这可能是预防肥胖的一个有前景的选择。
