Fuentes-Romero Beatriz, Muñoz-Prieto Alberto, Cerón José J, Martín-Cuervo María, Iglesias-García Manuel, Aguilera-Tejero Escolástico, Díez-Castro Elisa
Department of Equine Internal Medicine, University of Extremadura, 10004 Cáceres, Spain.
Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, University of Murcia, 30003 Murcia, Spain.
Animals (Basel). 2021 Dec 30;12(1):77. doi: 10.3390/ani12010077.
Obesity and its associated complications, such as metabolic syndrome, are an increasing problem in both humans and horses in the developed world. The expression patterns of resistin differ considerably between species. In rodents, resistin is expressed by adipocytes and is related to obesity and ID. In humans, resistin is predominantly produced by inflammatory cells, and resistin concentrations do not reflect the degree of obesity, although they may predict cardiovascular outcomes. The aim of this study was to investigate the usefulness of resistin and its relationship with ID and selected indicators of inflammation in horses. Seventy-two horses, included in one of the four following groups, were studied: healthy controls (C, n = 14), horses with inflammatory conditions (I, n = 21), horses with mild ID (ID1, n = 18), and horses with severe ID (ID2, n = 19). Plasma resistin concentrations were significantly different between groups and the higher values were recorded in the I and ID2 groups (C: 2.38 ± 1.69 ng/mL; I: 6.85 ± 8.38 ng/mL; ID1: 2.41 ± 2.70 ng/mL; ID2: 4.49 ± 3.08 ng/mL). Plasma resistin was not correlated with basal insulin concentrations. A significant (r = 0.336, = 0.002) correlation was found between resistin and serum amyloid A. Our results show that, as is the case in humans, plasma resistin concentrations in horses are predominantly related to inflammatory conditions and not to ID. Horses with severe ID showed an elevation in resistin that may be secondary to the inflammatory status associated with metabolic syndrome.
在发达国家，肥胖及其相关并发症，如代谢综合征，在人类和马匹中都是日益严重的问题。抵抗素的表达模式在不同物种之间有很大差异。在啮齿动物中，抵抗素由脂肪细胞表达，与肥胖和胰岛素抵抗有关。在人类中，抵抗素主要由炎症细胞产生，抵抗素浓度并不反映肥胖程度，尽管它们可能预测心血管疾病的发生。本研究的目的是探讨抵抗素在马匹中的作用及其与胰岛素抵抗和选定炎症指标的关系。研究了72匹马，它们被分为以下四组之一：健康对照组（C组，n = 14）、患有炎症性疾病的马（I组，n = 21）、患有轻度胰岛素抵抗的马（ID1组，n = 18）和患有严重胰岛素抵抗的马（ID2组，n = 19）。各组之间血浆抵抗素浓度有显著差异，I组和ID2组的抵抗素浓度较高（C组：2.38±1.69 ng/mL；I组：6.85±8.38 ng/mL；ID1组：2.41±2.70 ng/mL；ID2组：4.49±3.08 ng/mL）。血浆抵抗素与基础胰岛素浓度无关。抵抗素与血清淀粉样蛋白A之间存在显著相关性（r = 0.336，P = 0.002）。我们的研究结果表明，与人类一样，马匹血浆抵抗素浓度主要与炎症状态有关，而与胰岛素抵抗无关。患有严重胰岛素抵抗的马抵抗素升高可能继发于与代谢综合征相关的炎症状态。
