Laboratory of Cardiocirculatory, Respiratory, and Hormonal Adaptations to Muscular Exercise, Faculty of Medicine Ibn El Jazzar, University of Sousse, Sousse, Tunisia.
Obes Facts. 2013;6(4):393-404. doi: 10.1159/000354574. Epub 2013 Aug 16.
The link between plasma resistin and obesity-related cardiometabolic disorders in children remains debatable. This study assessed the relationships of plasma resistin with cardiovascular risk factors, pro-inflammatory markers and insulin resistance index (HOMA-IR) in obese (Ob) adolescents and obese adolescents with metabolic syndrome (Ob-MS) compared to healthy controls (CO).
114 obese adolescents (60 Ob, age 13.6 ± 0.9 years, BMI 28.0 ± 2.2 kg/m(2), and 54 Ob-MS, age 13.8 ± 1.0 years, BMI 32.5 ± 4.8 kg/m(2)) and 37 CO (age 13.7 ± 0.8 years, BMI 22.8 ± 0.8 kg/m(2)) were studied. Anthropometrics, cardiac variables as well as fasting plasma concentrations of lipids, glucose, insulin, and adipocytokines (resistin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP)) were measured. HOMA-IR was calculated, and the presence of MS was assessed.
Plasma resistin was significantly higher in Ob-MS than in both Ob and CO and was correlated with anthropometric, cardiovascular, pro-inflammatory markers and several components of MS as was HOMA-IR in Ob and Ob-MS. With increasing the number of MS components, plasma resistin, pro-inflammatory markers, and HOMA-IR were also increased. Multiple regression models highlighted significant correlation between resistin and both HOMA-IR (r = 0.40, p < 0.05) and systolic blood pressure (r = 0.63, p < 0.01) in Ob-MS.
These results support the hypothesis that there is an association between circulating resistin and childhood obesity-related inflammatory and cardiometabolic events.
血浆抵抗素与儿童肥胖相关心血管代谢紊乱之间的关系仍存在争议。本研究评估了肥胖青少年（Ob）和肥胖合并代谢综合征（Ob-MS）青少年与健康对照组（CO）相比，血浆抵抗素与心血管危险因素、促炎标志物和胰岛素抵抗指数（HOMA-IR）的关系。
研究了 114 名肥胖青少年（60 名 Ob，年龄 13.6±0.9 岁，BMI 28.0±2.2kg/m²，54 名 Ob-MS，年龄 13.8±1.0 岁，BMI 32.5±4.8kg/m²）和 37 名 CO（年龄 13.7±0.8 岁，BMI 22.8±0.8kg/m²）。测量了人体测量学、心脏变量以及空腹血浆中脂质、葡萄糖、胰岛素和脂肪细胞因子（抵抗素、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、C 反应蛋白（CRP））的浓度。计算了 HOMA-IR，并评估了 MS 的存在。
Ob-MS 组的血浆抵抗素显著高于 Ob 组和 CO 组，与 Ob 和 Ob-MS 的体重指数、心血管、促炎标志物和 MS 的几个组成部分均呈正相关。随着 MS 成分的增加，血浆抵抗素、促炎标志物和 HOMA-IR 也增加。多元回归模型突出了 Ob-MS 中抵抗素与 HOMA-IR（r=0.40，p<0.05）和收缩压（r=0.63，p<0.01）之间的显著相关性。
这些结果支持这样的假设，即循环抵抗素与儿童肥胖相关的炎症和心血管代谢事件之间存在关联。
